“BCL2L10”的意思、由来-开放百科全书

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.^[3]

References

1. ^{{cite journal | vauthors = Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nunez G | title = Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death | journal = J Biol Chem | volume = 273 | issue = 49 | pages = 32479–86 |date=Jan 1999 | pmid = 9829980 | pmc = | doi =10.1074/jbc.273.49.32479 }}
2. ^{{cite journal | vauthors = Song Q, Kuang Y, Dixit VM, Vincenz C | title = Boo, a novel negative regulator of cell death, interacts with Apaf-1 | journal = EMBO J | volume = 18 | issue = 1 | pages = 167–78 |date=Feb 1999 | pmid = 9878060 | pmc = 1171112 | doi = 10.1093/emboj/18.1.167 }}
3. ^¹{{cite web | title = Entrez Gene: BCL2L10 BCL2-like 10 (apoptosis facilitator)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10017| accessdate = }}

Further reading

{{cite journal | author=van Oirschot JT |title=Diva vaccines that reduce virus transmission |journal=J. Biotechnol. |volume=73 |issue= 2–3 |pages= 195–205 |year= 1999 |pmid= 10486928 |doi=10.1016/S0168-1656(99)00121-2 }}

{{cite journal | vauthors=Pan G, O'Rourke K, Dixit VM |title=Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5841–5 |year= 1998 |pmid= 9488720 |doi=10.1074/jbc.273.10.5841 }}

{{cite journal | vauthors=Ke N, Godzik A, Reed JC |title=Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12481–4 |year= 2001 |pmid= 11278245 |doi= 10.1074/jbc.C000871200 }}

{{cite journal | vauthors=Naumann U, Weit S, Wischhusen J, Weller M |title=Diva/Boo is a negative regulator of cell death in human glioma cells |journal=FEBS Lett. |volume=505 |issue= 1 |pages= 23–6 |year= 2001 |pmid= 11557035 |doi=10.1016/S0014-5793(01)02768-5 }}

{{cite journal | author=Aouacheria A |title=Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis |journal=Oncogene |volume=20 |issue= 41 |pages= 5846–55 |year= 2001 |pmid= 11593390 |doi= 10.1038/sj.onc.1204740 |name-list-format=vanc| author2=Arnaud E | author3=Venet S | display-authors=3 | last4=Lalle | first4=Philippe | last5=Gouy | first5=Manolo | last6=Rigal | first6=Dominique | last7=Gillet | first7=Germain }}

{{cite journal | vauthors=Zhang H, Holzgreve W, De Geyter C |title=Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway |journal=Hum. Mol. Genet. |volume=10 |issue= 21 |pages= 2329–39 |year= 2002 |pmid= 11689480 |doi=10.1093/hmg/10.21.2329 }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | vauthors=Li Z, Takeuchi S, Ohara N, Maruo T |title=Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma |journal=Int. J. Clin. Oncol. |volume=8 |issue= 2 |pages= 83–9 |year= 2003 |pmid= 12720100 |doi= 10.1007/s101470300015 }}

{{cite journal | author=Kang Y |title=NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 1 |pages= 76–82 |year= 2007 |pmid= 17532299 |doi= 10.1016/j.bbrc.2007.05.090 |name-list-format=vanc| author2=Lee DC | author3=Han J | display-authors=3 | last4=Yoon | first4=Seongmin | last5=Won | first5=Miae | last6=Yeom | first6=Ji-Hyun | last7=Seong | first7=Maeng-Je | last8=Ko | first8=Jeong-Jae | last9=Lee | first9=Kyung-Ah }}

{{cite journal | author=Guillemin Y |title=Oocytes and early embryos selectively express the survival factor BCL2L10 |journal=J. Mol. Med. |volume=87 |issue= 9 |pages= 923–40 |year= 2009 |pmid= 19551325 |doi= 10.1007/s00109-009-0495-7 |name-list-format=vanc| author2=Lalle P | author3=Gillet G | display-authors=3 | last4=Guerin | first4=Jean-François | last5=Hamamah | first5=Samir | last6=Aouacheria | first6=Abdel }}

References

Further reading

External links