| 词条 | Benign symmetric lipomatosis |
| 释义 |
| name = Benign symmetric lipomatosis | synonyms = Benign symmetric lipomatosis of Launois–Bensaude, Madelung's disease, multiple symmetric lipomatosis, cephalothoracic lipodystrophy | image = Benign symmetric lipomatosis.JPG | caption = A young man with benign symmetric lipomatosis (Madelung's disease) of unknown cause | pronounce = | field = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Benign symmetric lipomatosis is a skin condition characterized by extensive symmetric fat deposits in the head, neck, and shoulder girdle area.[1] The German surgeon Otto Wilhelm Madelung was the first to give a detailed description of the disorder. This condition is very rare, with an estimated incidence rate of 1 in 25,000, and affects males up to 30 times more frequently than females.[2] The cause of the disease remains unknown, but its incidence strongly correlates with alcohol abuse; abstinence from alcohol prevents disease progression. Defects in the adrenergic-stimulated lipolysis and accumulation of embryological brown fat have also been reported. Cosmetic disfigurement due to the fat deposition in the cervicothoracic region results in a "pseudoathletic appearance", resembling the Italian statue Warrior of Capestrano and carvings of Queen of Punt (Egypt).[3] Traditionally the treatment is mainly surgical, consisting of the removal of the lipomas, although recent study has proposed liposuction and phosphatidylcholine injection as possible alternatives.[4] SocietyThe appearance of people with the disease is depicted in:
See also
References1. ^{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=}} 2. ^{{cite journal |vauthors=González-García R, Rodríguez-Campo FJ, Sastre-Pérez J, Muñoz-Guerra MF |title=Benign symmetric lipomatosis (Madelung's disease): case reports and current management |journal=Aesthetic Plast Surg |volume=28 |issue=2 |pages=108–12; discussion 113 |year=2004 |pmid=15164232 |url= |doi=10.1007/s00266-004-3123-5}} 3. ^{{cite journal |author=Medappil Noushif |author2= Vasu TA |title=Madelung's disease: A spot diagnosis |journal=Indian J Plast Surg |volume= 43|issue= 2|pages= 227–8|date=July 2010 |pmid=21217991 |url= |doi=10.4103/0970-0358.73472 |pmc=3010793}} 4. ^{{cite journal |vauthors=Hasegawa T, Matsukura T, Ikeda S |title=Mesotherapy for Benign Symmetric Lipomatosis |journal=Aesthetic Plast Surg |volume= 34|issue= 2|pages= 153–6|date=June 2009 |pmid=19488808 |url= |doi=10.1007/s00266-009-9374-4}} 5. ^{{cite journal |author=Medappil Noushif |author2= Vasu TA |title=Madelung's disease: A spot diagnosis |journal=Indian J Plast Surg |volume= 43|issue= 2|pages= 227–8|date=July 2010 |pmid=21217991 |url= |doi=10.4103/0970-0358.73472 |pmc=3010793}} 6. ^{{cite book|author=Leon, Donna|title=Beastly Things (Commissario Brunetti, #21)|date=2012|publisher=Grove/Atlantic|url=http://www.goodreads.com/book/show/12862985-beastly-things|isbn=0802120237|page=5 of Chapter 3 }} External links{{Medical resources| DiseasesDB = | ICD10 = {{ICD10|E88.8}} (ILDS E88.820) | ICD9 = {{ICD9|272.8}} | ICDO = | OMIM = 151800 | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D008069 }}{{Soft tissue tumors and sarcomas}}{{Multiple abnormalities}}{{Cutaneous-condition-stub}} 2 : Conditions of the subcutaneous fat|Rare diseases |
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