请输入您要查询的百科知识：

　

词条 Bile salt sulfotransferase
释义

  1. Function

  2. See also

  3. References

  4. Further reading

  5. External links

{{Infobox_gene}}Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.[1][2][3]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.[1]

See also

  • Steroid sulfotransferase
  • Steroidogenic enzyme

References

1. ^1 {{cite web | title = Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6822| accessdate = }}
2. ^{{cite journal | vauthors = Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM | title = Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA | journal = Mol. Pharmacol. | volume = 41 | issue = 5 | pages = 865–72 |date=May 1992 | pmid = 1588921 | doi = | url = http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1588921 | issn = }}
3. ^{{cite journal | vauthors = Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM | title = Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3 | journal = Cytogenet. Cell Genet. | volume = 70 | issue = 1-2 | pages = 45–7 | year = 1995 | pmid = 7736787 | doi = 10.1159/000133988| url = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Weinshilboum RM, Otterness DM, Aksoy IA |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Glatt H, Engelke CE, Pabel U |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue= |pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3 |display-authors=etal}}
  • {{cite journal | vauthors=Glatt H, Boeing H, Engelke CE |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi= 10.1016/S0027-5107(01)00207-X|display-authors=etal}}
  • {{cite journal | vauthors=Kong AN, Yang L, Ma M |title=Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 1 |pages= 448–54 |year= 1992 |pmid= 1520333 |doi=10.1016/S0006-291X(05)81514-1 |display-authors=etal}}
  • {{cite journal | vauthors=Comer KA, Falany CN |title=Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal. |journal=Mol. Pharmacol. |volume=41 |issue= 4 |pages= 645–51 |year= 1992 |pmid= 1569919 |doi= }}
  • {{cite journal | vauthors=Otterness DM, Wieben ED, Wood TC |title=Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. |journal=Mol. Pharmacol. |volume=41 |issue= 5 |pages= 865–72 |year= 1992 |pmid= 1588921 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Radominska A, Comer KA, Zimniak P |title=Human liver steroid sulphotransferase sulphates bile acids. |journal=Biochem. J. |volume=272 |issue= 3 |pages= 597–604 |year= 1991 |pmid= 2268288 |doi= |pmc=1149750|display-authors=etal}}
  • {{cite journal | vauthors=Forbes KJ, Hagen M, Glatt H |title=Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. |journal=Mol. Cell. Endocrinol. |volume=112 |issue= 1 |pages= 53–60 |year= 1995 |pmid= 7589785 |doi=10.1016/0303-7207(95)03585-U |display-authors=etal}}
  • {{cite journal | vauthors=Luu-The V, Dufort I, Paquet N |title=Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. |journal=DNA Cell Biol. |volume=14 |issue= 6 |pages= 511–8 |year= 1995 |pmid= 7598806 |doi= 10.1089/dna.1995.14.511|display-authors=etal}}
  • {{cite journal | vauthors=Comer KA, Falany JL, Falany CN |title=Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. |journal=Biochem. J. |volume=289 |issue= 1|pages= 233–40 |year= 1993 |pmid= 7678732 |doi= |pmc=1132155}}
  • {{cite journal | vauthors=Otterness DM, Her C, Aksoy S |title=Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization. |journal=DNA Cell Biol. |volume=14 |issue= 4 |pages= 331–41 |year= 1995 |pmid= 7710689 |doi= 10.1089/dna.1995.14.331|display-authors=etal}}
  • {{cite journal | vauthors=Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM |title=Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 1-2 |pages= 45–7 |year= 1995 |pmid= 7736787 |doi=10.1159/000133988 }}
  • {{cite journal | vauthors=Falany CN, Wheeler J, Oh TS, Falany JL |title=Steroid sulfation by expressed human cytosolic sulfotransferases. |journal=J. Steroid Biochem. Mol. Biol. |volume=48 |issue= 4 |pages= 369–75 |year= 1994 |pmid= 8142314 |doi=10.1016/0960-0760(94)90077-9 }}
  • {{cite journal | vauthors=Barker EV, Hume R, Hallas A, Coughtrie WH |title=Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes. |journal=Endocrinology |volume=134 |issue= 2 |pages= 982–9 |year= 1994 |pmid= 8299591 |doi=10.1210/en.134.2.982 }}
  • {{cite journal | vauthors=Durocher F, Morissette J, Dufort I |title=Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region. |journal=Genomics |volume=29 |issue= 3 |pages= 781–3 |year= 1996 |pmid= 8575776 |doi= 10.1006/geno.1995.9935 |display-authors=etal}}
  • {{cite journal | vauthors=Rubin GL, Harrold AJ, Mills JA |title=Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. |journal=Mol. Hum. Reprod. |volume=5 |issue= 11 |pages= 995–1002 |year= 1999 |pmid= 10541560 |doi=10.1093/molehr/5.11.995 |display-authors=etal}}
  • {{cite journal | vauthors=Tashiro A, Sasano H, Nishikawa T |title=Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa. |journal=J. Steroid Biochem. Mol. Biol. |volume=72 |issue= 3-4 |pages= 149–54 |year= 2000 |pmid= 10775806 |doi=10.1016/S0960-0760(00)00020-0 |display-authors=etal}}
  • {{cite journal | vauthors=Pedersen LC, Petrotchenko EV, Negishi M |title=Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. |journal=FEBS Lett. |volume=475 |issue= 1 |pages= 61–4 |year= 2000 |pmid= 10854859 |doi=10.1016/S0014-5793(00)01479-4 }}
{{refend}}

External links

  • {{MeshName|alcohol+sulfotransferase}}
  • {{UCSC gene info|SULT2A1}}
{{PDB Gallery|geneid=6822}}{{Sulfur-containing group transferases}}{{transferase-stub}}{{genetics-stub}}

1 : Posttranslational modification
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/24 10:16:29