“Biotin attachment domain”的意思、由来-开放百科全书

词条

Biotin attachment domain

释义

Human proteins containing this domain
References

{{Orphan|date=May 2016}}{{Pfam box
| Symbol = Biotin_lipoyl
| Name = Biotin-requiring enzyme
| image =
| width =
| caption =
| Pfam= PF00364
| InterPro= IPR000089
| SMART=
| Prosite = PDOC00168
| SCOP = 1lab
| TCDB = 3.B.1
| CDD = cd06663
| OPM family=
| OPM protein=
| PDB={{PDB3|1dcz}}A:55-122 {{PDB3|1dd2}}A:55-122 {{PDB3|1o78}}A:55-122{{PDB3|1k67}}B:81-155 {{PDB3|2bdo}}A:81-155 {{PDB3|1k69}}B:81-155{{PDB3|3bdo}}A:81-155 {{PDB3|1bdo}} :81-155 {{PDB3|1a6x}} :81-155{{PDB3|1y8p}}B:186-260 {{PDB3|1y8n}}B:186-260 {{PDB3|1fyc}} :186-260{{PDB3|1y8o}}B:186-260 {{PDB3|1ghk}} :3-76 {{PDB3|1ghj}} :3-76{{PDB3|1gjx}}A:4-76 {{PDB3|1qjo}}A:207-278 {{PDB3|1iyu}} :3-73{{PDB3|1iyv}} :3-73 {{PDB3|1lac}} :3-76 {{PDB3|1lab}} :3-76{{PDB3|1k8m}}A:65-138 {{PDB3|1k8o}}A:65-138
}}

Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme.^[1] Lipoamide acyltransferases have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group.^[2] The lipoic acid cofactor is found in a variety of proteins.

Human proteins containing this domain

ACACA; ACACB; DBT; DLAT; DLST; DLSTP; MCCC1; PC;

PCCA; PDHX;

References

1. ^{{cite journal |vauthors=Kumar GK, Shenoy BC, Wood HG, Samols D, Xie Y, Park VL, Beegen H |title=The importance of methionine residues for the catalysis of the biotin enzyme, transcarboxylase. Analysis by site-directed mutagenesis |journal=J. Biol. Chem. |volume=267 |issue=26 |pages=18407–18412 |year=1992 |pmid=1526981}}
2. ^{{cite journal |vauthors=Guest JR, Russell GC |title=Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme |journal=Biochim. Biophys. Acta |volume=1076 |issue=2 |pages=225–232 |year=1991 |pmid=1825611 |doi=10.1016/0167-4838(91)90271-z}}

1 : Protein domains

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