| 词条 | Bithorax complex |
| 释义 |
The Bithorax complex (BX-C) is a group of homeotic genes in Drosophila melanogaster which control the differentiation of the abdominal and posterior thoracic segments, located on chromosome III.[1] When these genes are mutated, the third thoracic segment becomes a repeat of the second thoracic segment, creating what is essentially a second thorax. This can result in a second pair of wings, a second stomach, and duplicated thoracic features in varying degrees.[2] The complex includes the Ultrabithorax (Ubx), Abdominal A (abd-A) and Abdominal B (Abd-B) genes.[3] Calvin Bridges discovered the Bithorax (mutation/gene) in the fly in 1915; after that, Edward B. Lewis named and worked on the Bithorax complex[4] and proposed a model in a classic evolutionary developmental biology paper in Nature in 1978, for which he won a Nobel Prize.[5]References1. ^{{cite journal |doi=10.1038/308428a0 |title=A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes |year=1984 |last1=McGinnis |first1=W. |last2=Levine |first2=M. S. |last3=Hafen |first3=E. |last4=Kuroiwa |first4=A. |last5=Gehring |first5=W. J. |journal=Nature |volume=308 |issue=5958 |pages=428–33 |pmid=6323992}} {{DEFAULTSORT:Bithorax Complex}}{{genetics-stub}}2. ^{{cite journal |pmid=9666315 |year=1998 |last1=Dang |first1=KD |last2=Dutt |first2=PB |last3=Forsdyke |first3=DR |title=Chargaff difference analysis of the bithorax complex of Drosophila melanogaster |volume=76 |issue=1 |pages=129–37 |journal=Biochemistry and Cell Biology |doi=10.1139/bcb-76-1-129}} 3. ^Developmental biology. Scott F. Gilbert 4. ^{{cite journal |pmid=15611154 |year=2004 |last1=Crow |first1=JF |last2=Bender |first2=W |title=Edward B. Lewis, 1918-2004 |volume=168 |issue=4 |pages=1773–83 |pmc=1448758 |journal=Genetics}} 5. ^{{cite journal |doi=10.1038/276565a0 |title=A gene complex controlling segmentation in Drosophila |year=1978 |last1=Lewis |first1=E. B. |journal=Nature |volume=276 |issue=5688 |pages=565–70 |pmid=103000}} 1 : Drosophila melanogaster genes |
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