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{{Infobox_gene}}Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.[1][2][3]Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone.[4] Another of its activities is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.[3] InteractionsBLMH has been shown to interact with RPL29,[5] RPL11,[5] UBE2I[6] and Amyloid precursor protein.[7] References1. ^{{cite journal | vauthors = Ferrando AA, Pendas AM, Llano E, Velasco G, Lidereau R, Lopez-Otin C | title = Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase | journal = J Biol Chem | volume = 272 | issue = 52 | pages = 33298–304 |date=January 1998 | pmid = 9407121 | pmc = | doi =10.1074/jbc.272.52.33298 }}
2. ^{{cite journal | vauthors = Montoya SE, Ferrell RE, Lazo JS | title = Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase | journal = Cancer Res | volume = 57 | issue = 19 | pages = 4191–5 |date=October 1997 | pmid = 9331073 | pmc = | doi = }}
3. ^1 {{cite web | title = Entrez Gene: BLMH bleomycin hydrolase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=642| accessdate = }}
4. ^{{cite journal |title = Protective Mechanisms against Homocysteine Toxicity |author = Jarosław Zimny |author2 = Marta Sikora |author3 = Andrzej Guranowski |author4 = Hieronim Jakubowski |last-author-amp = yes |year = 2006 |journal = The Journal of Biological Chemistry |volume = 281 |pages = 22485–22492 |doi=10.1074/jbc.M603656200 |url = http://www.jbc.org/content/281/32/22485.abstract }}
5. ^1 {{cite journal |last=Koldamova |first=R P |author2=Lefterov I M|author3=DiSabella M T|author4=Almonte C|author5=Watkins S C|author6=Lazo J S |date=June 1999 |title=Human bleomycin hydrolase binds ribosomal proteins |journal=Biochemistry |volume=38 |issue=22 |pages=7111–7 |publisher= |location = UNITED STATES| issn = 0006-2960| pmid = 10353821 |doi = 10.1021/bi990135l | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
6. ^{{cite journal |last=Koldamova |first=R P |author2=Lefterov I M|author3=DiSabella M T|author4=Lazo J S |date=December 1998 |title=An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9 |journal=Mol. Pharmacol. |volume=54 |issue=6 |pages=954–61 |publisher= |location = UNITED STATES| issn = 0026-895X| pmid = 9855622 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
7. ^{{cite journal |doi=10.1096/fj.99-0938com |last=Lefterov |first=I M |author2=Koldamova R P|author3=Lazo J S |date=September 2000 |title=Human bleomycin hydrolase regulates the secretion of amyloid precursor protein |journal=FASEB J. |volume=14 |issue=12 |pages=1837–47 |publisher= |location = UNITED STATES| issn = 0892-6638| pmid = 10973933 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Ferrando AA, Velasco G, Campo E, Lopez-Otin C |title=Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. |journal=Cancer Res. |volume=56 |issue= 8 |pages= 1746–50 |year= 1996 |pmid= 8620487 |doi= }}
- {{cite journal | vauthors=Brömme D, Rossi AB, Smeekens SP |title=Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. |journal=Biochemistry |volume=35 |issue= 21 |pages= 6706–14 |year= 1996 |pmid= 8639621 |doi= 10.1021/bi960092y |display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS |title=Essential binding and functional domains of human bleomycin hydrolase. |journal=Biochemistry |volume=37 |issue= 8 |pages= 2282–90 |year= 1998 |pmid= 9485374 |doi= 10.1021/bi9722204 }}
- {{cite journal | vauthors=Montoya SE, Aston CE, DeKosky ST |title=Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 211–2 |year= 1998 |pmid= 9500538 |doi= 10.1038/ng0398-211 |display-authors=etal}}
- {{cite journal | vauthors=Zheng W, Johnston SA, Joshua-Tor L |title=The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. |journal=Cell |volume=93 |issue= 1 |pages= 103–9 |year= 1998 |pmid= 9546396 |doi=10.1016/S0092-8674(00)81150-2 }}
- {{cite journal | vauthors=Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS |title=An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9. |journal=Mol. Pharmacol. |volume=54 |issue= 6 |pages= 954–61 |year= 1999 |pmid= 9855622 |doi= }}
- {{cite journal | vauthors=Takeda A, Nonaka M, Ishikawa A, Higuchi D |title=Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin. |journal=Arch. Dermatol. Res. |volume=291 |issue= 4 |pages= 238–40 |year= 1999 |pmid= 10335922 |doi=10.1007/s004030050400 }}
- {{cite journal | vauthors=Koldamova RP, Lefterov IM, DiSabella MT |title=Human bleomycin hydrolase binds ribosomal proteins. |journal=Biochemistry |volume=38 |issue= 22 |pages= 7111–7 |year= 1999 |pmid= 10353821 |doi= 10.1021/bi990135l |display-authors=etal}}
- {{cite journal | vauthors=O'Farrell PA, Gonzalez F, Zheng W |title=Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. |journal=Structure |volume=7 |issue= 6 |pages= 619–27 |year= 1999 |pmid= 10404591 |doi=10.1016/S0969-2126(99)80083-5 |display-authors=etal}}
- {{cite journal | vauthors=Malherbe P, Faull RL, Richards JG |title=Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains. |journal=Neurosci. Lett. |volume=281 |issue= 1 |pages= 37–40 |year= 2000 |pmid= 10686410 |doi=10.1016/S0304-3940(00)00802-8 }}
- {{cite journal | vauthors=Lefterov IM, Koldamova RP, Lazo JS |title=Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. |journal=FASEB J. |volume=14 |issue= 12 |pages= 1837–47 |year= 2000 |pmid= 10973933 |doi=10.1096/fj.99-0938com }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal | vauthors=Nivet-Antoine V, Coulhon MP, Le Denmat C |title=[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases] |journal=Ann. Biol. Clin. (Paris) |volume=61 |issue= 1 |pages= 61–7 |year= 2003 |pmid= 12604387 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
{{refend}}{{PDB Gallery|geneid=642}}{{Cysteine proteases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-17-stub}} 1 : EC 3.4.22 |