| 释义 |
- Function
- Interactions
- References
- External links
- Further reading
{{Infobox_gene}}BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.[1][2] Function This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector.[2] InteractionsBNIP2 has been shown to interact with: - ARHGAP1,[4][5]
- Bcl-2,[1][3] and
- CDC42.[4][5][6]
References1. ^1 {{cite journal | vauthors = Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G | title = Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins | journal = Cell | volume = 79 | issue = 2 | pages = 341–51 |date=November 1994 | pmid = 7954800 | pmc = | doi =10.1016/0092-8674(94)90202-X }}
2. ^1 {{cite web | title = Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=663| accessdate = }}
3. ^{{cite journal | date = August 2003 | vauthors = Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J | title = BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis | journal = Biochem. Biophys. Res. Commun. | volume = 308 | issue = 2 | pages = 379–85 | pmid = 12901880 | doi = 10.1016/s0006-291x(03)01387-1}}
4. ^1 {{cite journal | date = December 2000 | vauthors = Low BC, Seow KT, Guy GR | title = The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37742–51 | pmid = 10954711 | doi = 10.1074/jbc.M004897200}}
5. ^1 {{cite journal | date = November 1999 | vauthors = Low BC, Lim YP, Lim J, Wong ES, Guy GR | title = Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42 | journal = J. Biol. Chem. | volume = 274 | issue = 46 | pages = 33123–30 | pmid = 10551883 | doi = 10.1074/jbc.274.46.33123}}
6. ^{{cite journal | date = May 2000 | vauthors = Low BC, Seow KT, Guy GR | title = Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2 | journal = J. Biol. Chem. | volume = 275 | issue = 19 | pages = 14415–22 | pmid = 10799524 | doi = 10.1074/jbc.275.19.14415}}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Belcredito S, Vegeto E, Brusadelli A |title=Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2 |journal=Brain Res. Brain Res. Rev. |volume=37 |issue= 1–3 |pages= 335–42 |year= 2002 |pmid= 11744098 |doi=10.1016/S0165-0173(01)00138-2 |display-authors=etal}}
- {{cite journal | vauthors=Ohi N, Tokunaga A, Tsunoda H |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314–25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493 |display-authors=etal}}
- {{cite journal | vauthors=Zhou YT, Soh UJ, Shang X |title=The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7483–92 |year= 2002 |pmid= 11741952 |doi= 10.1074/jbc.M109459200 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Shang X, Zhou YT, Low BC |title=Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1 |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45903–14 |year= 2003 |pmid= 12944407 |doi= 10.1074/jbc.M304514200 }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Zhou YT, Guy GR, Low BC |title=BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 263–74 |year= 2005 |pmid= 15652341 |doi= 10.1016/j.yexcr.2004.08.044 }}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
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