| 词条 | Brazilian hemorrhagic fever |
| 释义 |
| name = Brazilian hemorrhagic fever | synonyms = | image = | caption = | pronounce = | field = Infectious disease | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}{{Taxobox | name = Sabiá virus | virus_group = v | familia = Arenaviridae | genus = Arenavirus | subdivision_ranks = Species | subdivision = Sabiá virus }}Brazilian hemorrhagic fever (BzHF) is an infectious disease caused by the Sabiá virus, an arenavirus.[1] The Sabiá virus is one of the arenaviruses from South America to cause hemorrhagic fever.[2] It shares a common progenitor with the Junin virus, Machupo virus, Tacaribe virus, and Guanarito virus.[2] It is an enveloped RNA virus and is highly infectious and lethal.[3] Very little is known about this disease, but it is thought to be transmitted by the excreta of rodents.[1][3] There have only been three documented infections of the Sabiá virus, only one of which occurred naturally and the other two cases occurred in the clinical setting.[1] The only naturally occurring case was in 1990, when a female agricultural engineer who was staying in the neighborhood of Jardim Sabiá near São Paulo, Brazil contracted the disease. She presented with hemorrhagic fever and died.[1] Her autopsy showed liver necrosis.[1] A virologist who was studying the woman's disease contracted the virus but survived.[1] Ribavirin was not given in these first two cases.[1] Four years later, in 1994, a researcher was exposed to the virus in a level 3 biohazard facility at Yale University when a centrifuge bottle cracked, leaked, and released aerosolized virus particle.[1][4] He was successfully treated with ribavirin.[1][5] Ribavirin is thought to be effective in treating the illness, similar to other arenaviruses.[1][5] Compared to the patients who did not receive ribavirin, the patient who was treated with it had a shorter and less severe clinical course.[1] Symptomatic control such as fluids to address dehydration and bleeding may also be required.[5]The Sabiá virus is a biosafety Level 4 pathogen.[3] This virus has also been implicated as a means for bioterrorism, as it can be spread through aerosols.[6] See also
References1. ^1 2 3 4 5 6 7 8 9 10 {{cite journal |last=Barry |first=M. |last2=Russi |first2=M. |last3=Armstrong |first3=L. |last4=Geller |first4=D. |last5=Tesh |first5=R. |last6=Dembry |first6=L. |last7=Gonzalez |first7=J. P. |last8=Khan |first8=A. S. |last9=Peters |first9=C. J. |title=Treatment of a Laboratory-Acquired Sabiá Virus Infection |journal=N Engl J Med |year=1995 |volume=333 |issue=5 |pages=317–318 |doi=10.1056/NEJM199508033330505 |pmid=7596373 }} 2. ^1 {{cite journal | doi = 10.1006/viro.1996.0381 | title=Genetic Characterization and Phylogeny of Sabiá Virus, an Emergent Pathogen in Brazil | journal=Virology | date=1996 | volume=221 | issue=2 | pages=318–324 | first=JEAN PAUL J. | last=GONZALEZ | pmid=8661442}} 3. ^1 2 NRT Quick Reference Guide: Brazilian Hemorrhagic Fever (BzHF) 4. ^{{Cite journal | pmid = 9018837| year = 1997| author1 = Gandsman| first1 = E. J.| title = Sabia virus incident at Yale University| journal = American Industrial Hygiene Association Journal| volume = 58| issue = 1| pages = 51–3| last2 = Aaslestad| first2 = H. G.| last3 = Ouimet| first3 = T. C.| last4 = Rupp| first4 = W. D.| doi = 10.1080/15428119791013080}} 5. ^1 2 http://www.stanford.edu/group/virus/arena/2005/SabiaVirus.htm Sabia Virus 6. ^http://www.oregon.gov/DHS/ph/acd/bioterrorism/backvhf.pdf Viral Hemorrhagic Fevers and Bioterrorism External links{{Medical resources| DiseasesDB = | ICD10 = {{ICD10|A|96|8|a|90}} | ICD9 = | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }}{{Zoonotic viral diseases}} 2 : Animal viral diseases|Hemorrhagic fevers |
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