| 词条 | Bunazosin |
| 释义 | {{Drugbox | verifiedrevid = 437176910 | IUPAC_name = 1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one | image = Bunazosin.png | tradename = | Drugs.com = {{drugs.com|international|bunazosin}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 80755-51-7 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = 2472 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2378 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 9UUW4V7G2H | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 188185 | chemical_formula = | C=19 | H=27 | N=5 | O=3 | molecular_weight = 373.44 g/mol | smiles = CCCC(=O)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C19H27N5O3/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19/h11-12H,4-10H2,1-3H3,(H2,20,21,22) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = RHLJLALHBZGAFM-UHFFFAOYSA-N }} Bunazosin (INN) is an alpha 1 antagonist. Bunazosin was initially developed to treat benign prostatic hyperplasia (BPH). It has been approved in Japan in a topical form to treat glaucoma. The mechanism of action is a reduction of aqueous outflow through the uveoscleral pathway resulting in lowering the intraocular pressure. It also may act to improve blood flow to the ocular nerve. Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome (IFIS). Bunazosin potentially could have the same effect but there has been no research to substantiate this as a risk for cataract surgery. {{antihypertensive-stub}} 5 : Alpha blockers|Phenol ethers|Quinazolines|Carboxamides|Diazepanes |
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