| 词条 | Bunyamwera orthobunyavirus |
| 释义 |
| image = | image_alt = | image_caption = | parent = Orthobunyavirus | species = Bunyamwera orthobunyavirus | authority = | synonyms = Bunyamwera virus | synonyms_ref = [1] | subdivision_ranks = Isolates[2] | subdivision =
}} Bunyamwera orthobunyavirus (BUNV) is a negative-sense, single-stranded enveloped RNA virus. It is the type species of the Orthobunyavirus genus, in the Bunyavirales order. Bunyamwera orthobunyavirus can infect both humans and Aedes aegypti (yellow fever mosquito).[3]It is named for Bunyamwera, a town in western Uganda, where the type species was isolated in 1943. Reassortant viruses derived from Bunyamwera orthobunyavirus, such as Ngari virus, which has been associated with large outbreaks of viral haemorrhagic fever in Kenya and Somalia.[4][5][6] Molecular biologyThe genetic structure of Bunyamwera orthobunyavirus is typical for Bunyavirales viruses, which are an order of enveloped negative-sense, single-stranded RNA viruses with a genome split into three parts—Small (S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins (Gc and Gn) and a nonstructural protein (NSm), while the S RNA segment encodes a nucleocapsid protein (N) and, in an alternative overlapping reading frame, a second nonstructural protein (NSs).[7] The genomic RNA segments are encapsidated by copies of the N protein in the form of ribonucleoprotein (RNP) complexes.[8] The N protein is the most abundant protein in virus particles and infected cells and, therefore, the main target in many serological and molecular diagnostics.[9][10] Disease in humans{{Infobox medical condition (new)| name = Bunyamwera fever | synonyms = | image = | alt = | caption = | pronounce = | field = Infectious disease | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} In humans, Bunyamwera orthobunyavirus causes Bunyamwera fever. References1. ^{{cite web |title=ICTV Taxonomy history: Bunyamwera orthobunyavirus |url=https://talk.ictvonline.org/taxonomy/p/taxonomy-history?taxnode_id=20180100 |website=International Committee on Taxonomy of Viruses (ICTV) |accessdate=31 January 2019 |language=en |format=html}} 2. ^{{cite web |title=ICTV 9th Report (2011) Bunyaviridae |url=https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/205/bunyaviridae |website=International Committee on Taxonomy of Viruses (ICTV) |accessdate=31 January 2019 |language=en |format=html |quote=Bunya: from Bunyamwera, place in Uganda, where type virus was isolated.}} 3. ^{{Cite web | url=https://www.uniprot.org/taxonomy/35304 | title=Bunyamwera virus (BUNV)}} 4. ^{{Cite journal|url = |title = Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa|vauthors = Gerrard SR, Li L, Barrett AD, Nichol ST|date = 2004|journal = J Virol |doi = 10.1128/JVI.78.16.8922-8926.2004|pmid = 15280501|pmc = 479050|access-date =|volume=78|issue = 16|pages=8922–6}} 5. ^{{Cite journal|title = Genome sequence analysis of in vitro and in vivo phenotypes of Bunyamwera and Ngari virus isolates from northern Kenya|vauthors = Odhiambo C, Venter M, Limbaso K, Swanepoel R, Sang R|date = 2014|journal = PLOS ONE |doi = 10.1371/journal.pone.0105446|pmid = 25153316|access-date =|pmc=4143288|volume=9|issue = 8|pages=e105446|bibcode = 2014PLoSO...9j5446O}} 6. ^{{cite journal|last1=Briese|first1=T.|last2=Bird|first2=B.|last3=Kapoor|first3=V.|last4=Nichol|first4=S. 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