| 词条 | Buthionine sulfoximine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477374857 | ImageFile=Buthionine sulfoximine.svg | ImageSize= | ImageAlt = Skeletal formula of buthionine sulfoximine | ImageFile1 = Buthionine-sulfoximine-zwitterion-3D-balls.png | ImageAlt1 = Ball-and-stick model of buthionine sulfoximine as a zwitterion | IUPACName=2-amino-4-(butylsulfonimidoyl)butanoic acid | OtherNames= BSO |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|changed|??}} | CASNo=5072-26-4 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 28714 | PubChem=21157 | SMILES=CCCCS(=N)(=O)CCC(C(=O)O)N | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 19896 | InChI = 1/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12) | InChIKey = KJQFBVYMGADDTQ-UHFFFAOYAW | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = KJQFBVYMGADDTQ-UHFFFAOYSA-N | MeSHName=Buthionine+sulfoximine |Section2={{Chembox Properties | Formula=C8H18N2O3S | MolarMass=222.305 g/mol | Appearance= | Density=1.29 g/mL | MeltingPtC=215 | BoilingPtC=382.3 | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Buthionine sulfoximine (BSO) is a sulfoximine which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer.[1] The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.[2] References1. ^{{cite journal|last1=Defty|first1=CL|last2=Marsden|first2=JR|title=Melphalan in regional chemotherapy for locally recurrent metastatic melanoma.|journal=Current Topics in Medicinal Chemistry|date=2012|volume=12|issue=1|pages=53–60|pmid=22196271}} {{organic-compound-stub}}2. ^{{cite web |url=http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=39123 |title=Definition of buthionine sulfoximine - National Cancer Institute Drug Dictionary |format= |work= |accessdate=}} 3 : Amino acids|Antineoplastic drugs|Sulfoximines |
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