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词条 Butofilolol
释义

  1. References

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477374938
| IUPAC_name = (RS)-1-[2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-fluorophenyl]butan-1-one
| image = Butofilolol skeletal.svg
| tradename =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 64552-17-6
| CAS_supplemental =
| ATC_prefix = none
| ATC_suffix =
| ATC_supplemental =
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 157443
| PubChem = 68838
| IUPHAR_ligand =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 4AZC6Y5A8G
| synonyms = CM-6805
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 62071
| chemical_formula =
| C=17 | H=26 | F=1 | N=1 | O=3
| molecular_weight = 311.392 g/mol
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H26FNO3/c1-5-6-15(21)14-9-12(18)7-8-16(14)22-11-13(20)10-19-17(2,3)4/h7-9,13,19-20H,5-6,10-11H2,1-4H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = NMBNQRJDEPOXCP-UHFFFAOYSA-N
| smiles = Fc1ccc(OCC(O)CNC(C)(C)C)c(c1)C(=O)CCC
}}

Butofilolol (trade name Cafide) is a beta-blocker drug for the treatment of essential hypertension (high blood pressure).[1][2] It is not known to be marketed anywhere.

References

1. ^{{Cite journal | last1 = Houin | first1 = G | last2 = Barre | first2 = J | last3 = Jeanniot | first3 = JP | last4 = Ledudal | first4 = P | last5 = Cautreels | first5 = W | last6 = Tillement | first6 = JP | title = Pharmacokinetics of butofilolol (CAFIDE) after repeated oral administration in man | journal = International Journal of Clinical Pharmacology Research | volume = 4 | issue = 3 | pages = 175–83 | year = 1984 | pmid = 6149195}}
2. ^{{Cite journal | last1 = Toussain | first1 = P | last2 = Gay | first2 = G | last3 = Debry | first3 = G | title = Long-term hypotensive treatment by butofilolol | journal = Annales de Cardiologie et d'Angeiologie | volume = 32 | issue = 4 | pages = 277–83 | year = 1983 | pmid = 6412614}}
{{Adrenergics}}{{antihypertensive-stub}}

1 : Beta blockers

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