请输入您要查询的百科知识：

　

词条 C11orf16
释义

  1. Gene

     Location  Gene Neighborhood  Expression  Human  Mouse Brain  Transcription Factors 

  2. mRNA

     Isoform 

  3. Homology

     Paralogs  Orthologs  Conservation 

  4. Protein

     Molecular Weight  Domains and Motifs  Secondary Structure  Post-translational Modifications  Subcellular Localization Predictor  Protein Interaction 

  5. Clinical Significance

     Disease Association 

  6. References

  7. External links

  8. Further reading

{{Infobox_gene}}

Gene C11orf16, chromosome 11 open reading frame 16, is a protein in humans that is encoded by the C11orf16 gene.[1][2] It has 7 exons, and the size of 467 amino acids.

Gene

Location

The gene C11orf16 is located on chromosome 11(p15.4), starting at 8,920,076bp and ending at 8,933,006bp.

Gene Neighborhood

Gene ASCL3 and AKIP1 are the neighbor genes of C11orf16 on Chromosome 11.

Expression

Human

The gene does not have high expression throughout the body tissues. The percentile rank within the sample are higher in pancreas, ovary, and appendix.

Mouse Brain

Even though the gene does not have a significant high expression in the mouse brain, it is most expressed in midbrain, isocortex, olfactory areas, and medulla.

Transcription Factors

Some transcription factors that have the higher martix similarity are Kruppel-like zinc finger protein 219, Zinc finger protein 263, ZKSCAN12 (zinc finger protein with KRAB and SCAN domains 12), chorion-specific transcription factor GCMa, and Ras-responsive element binding protein 1.[3]

mRNA

Isoform

The predicted C11orf16 transcript variant X1 is 2386bp long and has NCBI accession number of XM_017018013.1.[4]

Homology

Paralogs

No paralogs were found for the C11orf16 gene through NCBI BLAST.

Orthologs

Description Common Name NCBI accession ID Query Cover E value Identity Date of Divergent (MYA)
Homo sapiens Human NP_065694.2 100 % 0 100% N/A
Pongo abelii Sumatran orangutan PNJ24628 84% 0 95% 15.2
Aotus nancymaae Nancy Ma's night monkey XP_012312127.1 88% 0 84% 42.6
Chinchilla lanigera Long-tailed chinchilla XP_013367496.1 97% 0 68% 88
Equus przewalskii Przewalski's horse XP_008512245.1 98% 0 73% 94
Cervus elaphus hippelaphus Central European red deer OWK17675.1 99% 0 67% 94
Hipposideros armiger Great roundleaf bat XP_019511755.1 99% 0 65% 94
Neomonachus schauinslandi Hawaiian monk seal XP_021541375.1 99% 0 66% 94
Lipotes vexillifer Baiji XP_007459933.1 98% 0 68% 94
Myotis brandtii Brandt's bat XP_005874017.1 98% 1e-174 67% 94
Chelonia mydas Green sea turtle XP_007057171.1 83% 1e-57 37% 320
Balearica regulorum gibbericeps Grey crowned crane XP_010311948.1 70% 6e-5 40% 320

Conservation

The gene C11orf16 is conserved in many animal species including mammals, avians, and reptiles.

Protein

Molecular Weight

The predicted molecular weight of the protein encoded by C11orf16 is 51 kiloDaltons.[5][6]

Domains and Motifs

Several protein domains and motifs were found including CHD5-like protein, Tyrosine kinase phosphorylation site, Protein kinase C phosphorylation site, N-myristoylation site, Casein kinase II phosphorylation site, and cGMP-dependent protein kinase phosphorylation site.[7] The picture indicates the location of the motifs.

Secondary Structure

The protein is predicted to be made up with 21.2% of alpha helix, 15.2% of extended strand, and 63% of random coil.

Post-translational Modifications

No transmembrane helices[8], potential GPI-modification site, and TM-protein were found. There were 7 predicted sumoylation sites[9], multiple phosporylation cites with most of them being unsp[10], and 9 glycosylation cites[11].

Subcellular Localization Predictor

The protein is predicted to be localized to the nucleus with the probability of 47.8%; mitochondria with the probability of 26.1%.[13]

Protein Interaction

Proteins C1orf105(Chromosome 1 open reading frame105 ), PWWP2A, and SMYD1(SET and MYND domain containing 1) were found to be interacting with C11orf16[14].

Clinical Significance

Disease Association

Protein coded by C11orf16 gene is also predicted to have 19.61% sequence identity to tumor suppressor p53-binding protein suggesting that this gene might be involved with tumor suppressing process[15].

References

1. ^{{cite journal|vauthors=Amid C, Bahr A, Mujica A, Sampson N, Bikar SE, Winterpacht A, Zabel B, Hankeln T, Schmidt ER|date=Aug 2001|title=Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7|journal=Cytogenet Cell Genet|volume=93|issue=3–4|pages=284–90|doi=10.1159/000056999|pmc=|pmid=11528127}}
2. ^{{cite web|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56673|title=Entrez Gene: C11orf16 chromosome 11 open reading frame 16|accessdate=}}
3. ^{{cite web|title=Genomatix|url=https://www.genomatix.de/?s=f235485dde95ccac200db8865073698a}}
4. ^{{cite web|title=NCBI Nucleotide|url=https://www.ncbi.nlm.nih.gov/nuccore/XM_017018013.1}}
5. ^{{cite web|title=Expasy|url=https://web.expasy.org/compute_pi/}}
6. ^{{cite web|title=Sigma Antibodies|url=https://www.sigmaaldrich.com/catalog/product/sigma/sab2106115?lang=en®ion=US}}
7. ^{{cite web|title=Motif Scan|url=https://myhits.isb-sib.ch/cgi-bin/motif_scan}}
8. ^{{cite web|title=TMHMM|url=http://www.cbs.dtu.dk/services/TMHMM/}}
9. ^{{cite web|title=SUMOplot|url=http://www.abgent.com/sumoplot}}
10. ^{{cite web|title=NetPhos|url=http://www.cbs.dtu.dk/services/NetPhos}}
11. ^{{cite web|title=YingOYang|url=http://www.cbs.dtu.dk/services/YinOYang/}}
12. ^{{cite web|title=PROTTER|url=http://wlab.ethz.ch/protter/start/}}
13. ^{{cite web|title=PSORTII|url=https://psort.hgc.jp/cgi-bin/runpsort.pl}}
14. ^{{cite web|title=STRING|url=https://string-db.org/}}
15. ^{{cite web|title=SWISS-MODEL|url=https://swissmodel.expasy.org/interactive/c4PYLU/models/}}

External links

  • {{UCSC gene info|C11orf16}}
  • C11orf16 information on [https://www.genecards.org/cgi-bin/carddisp.pl?gene=C11orf16 GeneCards]

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{refend}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/18 15:59:41