| 释义 |
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene.[1][2][3]The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.[3] InteractionsC1QBP has been shown to interact with Protein kinase D1,[4] BAT2,[5] PRKCD,[4] PKC alpha[4] and Protein kinase Mζ.[4] References1. ^{{cite journal | vauthors = Deb TB, Datta K | title = Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2 | journal = J Biol Chem | volume = 271 | issue = 4 | pages = 2206–12 |date=March 1996 | pmid = 8567680 | pmc = | doi = 10.1074/jbc.271.4.2206}}
2. ^{{cite journal | vauthors = Ghebrehiwet B, Lim BL, Peerschke EI, Willis AC, Reid KB | title = Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q | journal = J Exp Med | volume = 179 | issue = 6 | pages = 1809–21 |date=June 1994 | pmid = 8195709 | pmc = 2191527 | doi =10.1084/jem.179.6.1809 }}
3. ^1 {{cite web | title = Entrez Gene: C1QBP complement component 1, q subcomponent binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=708| accessdate = }}
4. ^1 2 3 {{cite journal |last=Storz |first=P |author2=Hausser A |author3=Link G |author4=Dedio J |author5=Ghebrehiwet B |author6=Pfizenmaier K |author7=Johannes F J |date=August 2000 |title=Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32 |journal=J. Biol. Chem. |volume=275 |issue=32 |pages=24601–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10831594 |doi = 10.1074/jbc.M002964200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
5. ^{{cite journal |doi=10.1016/S0888-7543(03)00235-0 |last=Lehner |first=Ben |author2=Semple Jennifer I |author3=Brown Stephanie E |author4=Counsell Damian |author5=Campbell R Duncan |author6=Sanderson Christopher M |date=January 2004 |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue=1 |pages=153–67 |publisher= |location = United States| issn = 0888-7543| pmid = 14667819 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Krainer AR, Mayeda A, Kozak D, Binns G |title=Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. |journal=Cell |volume=66 |issue= 2 |pages= 383–94 |year= 1991 |pmid= 1830244 |doi=10.1016/0092-8674(91)90627-B }}
- {{cite journal | vauthors=Busby TF, Ingham KC |title=NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q. |journal=Biochemistry |volume=29 |issue= 19 |pages= 4613–8 |year= 1990 |pmid= 2372546 |doi=10.1021/bi00471a016 }}
- {{cite journal | vauthors=Fridell RA, Harding LS, Bogerd HP, Cullen BR |title=Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. |journal=Virology |volume=209 |issue= 2 |pages= 347–57 |year= 1995 |pmid= 7778269 |doi= 10.1006/viro.1995.1266 }}
- {{cite journal | vauthors=Luo Y, Yu H, Peterlin BM |title=Cellular protein modulates effects of human immunodeficiency virus type 1 Rev. |journal=J. Virol. |volume=68 |issue= 6 |pages= 3850–6 |year= 1994 |pmid= 8189522 |doi= | pmc=236890 }}
- {{cite journal | vauthors=Honoré B, Madsen P, Rasmussen HH |title=Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2. |journal=Gene |volume=134 |issue= 2 |pages= 283–7 |year= 1994 |pmid= 8262387 |doi=10.1016/0378-1119(93)90108-F |display-authors=etal}}
- {{cite journal | vauthors=Tange TO, Jensen TH, Kjems J |title=In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10066–72 |year= 1996 |pmid= 8626563 |doi=10.1074/jbc.271.17.10066 }}
- {{cite journal | vauthors=Guo N, Weremowicz S, Lynch N |title=Assignment of C1QBP encoding the C1q globular domain binding protein (gC1q-R) to human chromosome 17 band p13.3 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 283–4 |year= 1997 |pmid= 9284938 |doi=10.1159/000134598 |display-authors=etal}}
- {{cite journal | vauthors=Majumdar M, Datta K |title=Assignment of cDNA encoding hyaluronic acid-binding protein 1 to human chromosome 17p12-p13. |journal=Genomics |volume=51 |issue= 3 |pages= 476–7 |year= 1998 |pmid= 9721222 |doi= 10.1006/geno.1998.5364 }}
- {{cite journal | vauthors=Petersen-Mahrt SK, Estmer C, Ohrmalm C |title=The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 1014–24 |year= 1999 |pmid= 10022843 |doi= 10.1093/emboj/18.4.1014 | pmc=1171193 |display-authors=etal}}
- {{cite journal | vauthors=Jiang J, Zhang Y, Krainer AR, Xu RM |title=Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3572–7 |year= 1999 |pmid= 10097078 |doi=10.1073/pnas.96.7.3572 | pmc=22335 |bibcode=1999PNAS...96.3572J }}
- {{cite journal | vauthors=Braun L, Ghebrehiwet B, Cossart P |title=gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes. |journal=EMBO J. |volume=19 |issue= 7 |pages= 1458–66 |year= 2000 |pmid= 10747014 |doi= 10.1093/emboj/19.7.1458 | pmc=310215 }}
- {{cite journal | vauthors=Beatch MD, Hobman TC |title=Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria. |journal=J. Virol. |volume=74 |issue= 12 |pages= 5569–76 |year= 2000 |pmid= 10823864 |doi=10.1128/JVI.74.12.5569-5576.2000 | pmc=112044 }}
- {{cite journal | vauthors=Storz P, Hausser A, Link G |title=Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24601–7 |year= 2000 |pmid= 10831594 |doi= 10.1074/jbc.M002964200 |display-authors=etal}}
- {{cite journal | vauthors=Tye AJ, Ghebrehiwet B, Guo N |title=The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17069–75 |year= 2001 |pmid= 11278463 |doi= 10.1074/jbc.M009064200 |display-authors=etal}}
- {{cite journal | vauthors=Schaerer MT, Kannenberg K, Hunziker P |title=Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26597–604 |year= 2001 |pmid= 11350968 |doi= 10.1074/jbc.M102534200 |display-authors=etal}}
- {{cite journal | vauthors=Kobayashi M, Hanai R |title=M phase-specific association of human topoisomerase IIIbeta with chromosomes. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 282–7 |year= 2001 |pmid= 11549288 |doi= 10.1006/bbrc.2001.5580 }}
- {{cite journal | vauthors=Rozanov DV, Ghebrehiwet B, Postnova TI |title=The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9318–25 |year= 2002 |pmid= 11773076 |doi= 10.1074/jbc.M110711200 |display-authors=etal}}
- {{cite journal | vauthors=Majumdar M, Meenakshi J, Goswami SK, Datta K |title=Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 4 |pages= 829–37 |year= 2002 |pmid= 11866440 |doi= 10.1006/bbrc.2002.6491 }}
{{refend}}External links{{PDB Gallery|geneid=708}}{{gene-17-stub}} |