词条 | Hemostasis |
释义 |
Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). It is the first stage of wound healing. This involves coagulation, blood changing from a liquid to a gel. Intact blood vessels are central to moderating blood's tendency to form clots. The endothelial cells of intact vessels prevent blood clotting with a heparin-like molecule and thrombomodulin and prevent platelet aggregation with nitric oxide and prostacyclin. When endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor which initiate the maintenance of hemostasis after injury. Hemostasis has three major steps: 1) vasoconstriction, 2) temporary blockage of a break by a platelet plug, and 3) blood coagulation, or formation of a fibrin clot. These processes seal the hole until tissues are repaired. Etymology and pronunciationThe word hemostasis ({{IPAc-en|ˌ|h|iː|m|oʊ-|ˈ|s|t|eɪ|s|ᵻ|s|}},{{refn|{{MerriamWebsterDictionary|accessdate=2016-01-21|hemostasis}}}}{{refn|{{OxfordDictionaries.com|accessdate=2016-01-21|hemostasis}}}} sometimes {{IPAc-en|ˌ|h|iː|ˈ|m|ɒ|s|t|ə|s|ᵻ|s}}) uses the combining forms hemo- and -stasis, New Latin from Ancient Greek αἱμο- haimo- (akin to αἷμα haîma), "blood", and στάσις stásis, "stasis", yielding "motionlessness or stopping of blood". Steps of mechanism{{Further|Coagulation}}Hemostasis occurs when blood is present outside of the body or blood vessels. It is the innate response for the body to stop bleeding and loss of blood. During hemostasis three steps occur in a rapid sequence. Vascular spasm is the first response as the blood vessels constrict to allow less blood to be lost. In the second step, platelet plug formation, platelets stick together to form a temporary seal to cover the break in the vessel wall. The third and last step is called coagulation or blood clotting. Coagulation reinforces the platelet plug with fibrin threads that act as a "molecular glue".[1] Platelets are a large factor in the hemostatic process. They allow for the creation of the "platelet plug" that forms almost directly after a blood vessel has been ruptured. Within seconds of a blood vessel's epithelial wall being disrupted platelets begin to adhere to the sub-endothelium surface. It takes approximately sixty seconds until the first fibrin strands begin to intersperse among the wound. After several minutes the platelet plug is completely formed by fibrin.[1] Hemostasis is maintained in the body via three mechanisms:
TypesHemostasis can be achieved in various other ways if the body cannot do it naturally (or needs help) during surgery or medical treatment. When the body is under shock and stress, hemostasis is harder to achieve. Though natural hemostasis is most desired, having other means of achieving this is vital for survival in many emergency settings. Without the ability to stimulate hemostasis the risk of hemorrhaging is great. During surgical procedures the types of hemostasis listed below can be used to control bleeding while avoiding and reducing the risk of tissue destruction. Hemostasis can be achieved by chemical agent as well as mechanical or physical agents. Which hemostasis type used is determined based on the situation.[5] Developmental Haemostasis refers to the differences in the haemostatic system between children and adults. In emergency medicineDebates by physicians and medical practitioners still continue to arise on the subject of hemostasis and how to handle situations with large injuries. If an individual acquires a large injury resulting in extreme blood loss, then a hemostatic agent alone would not be very effective. Medical professionals continue to debate on what the best ways are to assist a patient in a chronic state; however, it is universally accepted that hemostatic agents are the primary tool for smaller bleeding injuries.[5] Some main types of hemostasis used in emergency medicine include:
DisordersThe body's hemostasis system requires careful regulation in order to work properly. If the blood does not clot sufficiently, it may be due to bleeding disorders such as hemophilia or immune thrombocytopenia; this requires careful investigation. Over-active clotting can also cause problems; thrombosis, where blood clots form abnormally, can potentially cause embolisms, where blood clots break off and subsequently become lodged in a vein or artery. Hemostasis disorders can develop for many different reasons. They may be congenital, due to a deficiency or defect in an individual's platelets or clotting factors. A number of disorders can be acquired as well, such as in HELLP syndrome, which is due to pregnancy, or Hemolytic-uremic syndrome (HUS), which is due to E. coli toxins. History of artificial hemostasisThe process of preventing blood loss from a vessel or organ of the body is referred to as hemostasis. The term comes from the Ancient Greek roots "heme" meaning blood, and "stasis" meaning halting; Put together means the "halting of the blood".[10] The origin of hemostasis dates back as far as ancient Greece; first referenced to being used in the Battle of Troy. It started with the realization that excessive bleeding inevitably equaled death. Vegetable and mineral styptics were used on large wounds by the Greeks and Romans until the takeover of Egypt around 332BC by Greece. At this time many more advances in the general medical field were developed based off the study of Egyptian mummification practice, which led to greater knowledge of the hemostatic process. It was during this time that many of the veins and arteries running throughout the human body were found and the directions in which they traveled. Doctors of this time realized if these were plugged, blood could not continue to flow out of the body. Nevertheless, it took until the invention of the printing press during the fifteenth century for medical notes and ideas to travel westward, allowing for the idea and practice of hemostasis to be expanded.[11] ResearchThere is currently a great deal of research being conducted on hemostasis. The most current research is based on genetic factors of hemostasis and how it can be altered to reduce the cause of genetic disorders that alter the natural process hemostasis.[12] Von Willebrand disease is associated with a defect in the ability of the body to create the platelet plug and the fibrin mesh that ultimately stops the bleeding. New research is concluding that the von Willebrand disease is much more common in adolescence. This disease negatively hinders the natural process of Hemostasis causing excessive bleeding to be a concern in patients with this disease. There are complex treatments that can be done including a combination of therapies, estrogen-progesterone preparations, desmopressin, and Von Willebrand factor concentrates. Current research is trying to find better ways to deal with this disease; however, much more research is needed in order to find out the effectiveness of the current treatments and if there are more operative ways to treat this disease.[13]References1. ^Boon, G. D. "An Overview of Hemostasis." Toxicologic Pathology 21.2 (1993): 170-79. 2. ^1 {{Cite book|title=The Surgical Review: An Integrated Basic and Clinical Science Study Guide|last=Alturi|first=Pavan|publisher=Lippincott Williams & Wilkins.|year=2005|isbn=|location=Philadelphia|pages=300}} 3. ^{{Cite book|title=Essentials of pathophysiology for pharmacy|last=Zdanowicz|first=M|publisher=CRC Press|year=2003|isbn=|location=Florida|pages=23}} 4. ^{{Cite journal|last=Li|first=Zhenyu|date=11 Nov 2010|title=Signaling during platelet adhesion and activation|url=|journal=Arteriosclerosis, Thrombosis, and Vascular Biology|doi=10.1161/ATVBAHA.110.207522|pmid=|access-date=|volume=30|pages=2341–2349|pmc=3085271}} 5. ^1 {{cite journal | author = Kulkarni Roshni | year = 2004 | title = Alternative and Topical Approaches to Treating the Massicely Bleeding Patient | url = http://www.clinicaladvances.com/article_pdfs/ho-article-200407-hem.pdf | format = PDF | journal = Advances in Hematology | volume = 2 | issue = 7| pages = 428–31 }} 6. ^Aldo Moraci, et al. "The Use Of Local Agents: Bone Wax, Gelatin, Collagen, Oxidized Cellulose." European Spine Journal 2004; 13.: S89-S96. 7. ^{{cite journal |author1=Smith Shondra L. |author2=Belmont John M. |author3=Casparian J. Michael | year = 1999 | title = Analysis Of Pressure Achieved By Various Materials Used For Pressure Dressings | url = | journal = Dermatologic Surgery | volume = 25 | issue = 12| pages = 931–934 | doi=10.1046/j.1524-4725.1999.99151.x}} 8. ^{{cite journal | author = Kozak Orhan| year = 2010 | title = A New Method For Hepatic Resection And Hemostasis: Absorbable Plaque And Suture | url = | journal = Eurasian Journal of Medicine | volume = 41 | issue = | pages = 1–4 |display-authors=etal}} 9. ^{{cite journal | author = Tahriri Mohammadreza| year = 2011 | title = Preparation And Characterization Of Absorbable Hemostat Crosslinked Gelatin Sponges For Surgical Applications | url = | journal = Current Applied Physics | volume = 11 | issue = 3| pages = 457–461 |display-authors=etal}} 10. ^1 2 {{cite book|last1=Marieb|first1=Elaine Nicpon|first2=Katja|last2=Hoehn|title=Human Anatomy & Physiology|edition=8th|location=San Francisco|publisher=Benjamin Cummings|year=2010|pages=649–50}} 11. ^{{Cite journal|title=Wies, C. H. "The History of Hemostasis." Yale Journal of Biology and Medicine 2|year=1929|pages=167–68|pmc=2606227}} 12. ^{{cite journal |last1=Rosen |first1=Elliot D. |last2=Xuei |first2=Xiaoling |last3=Suckow |first3=Mark |last4=Edenberg |first4=Howard |date=2006 |title=Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII |journal=Blood Cells, Molecules and Diseases |volume=36 |issue=2 |pages=131–134 |doi=10.1016/j.bcmd.2005.12.037}} 13. ^{{cite journal |last1=Mikhail |first1=Sameh |last2=Kouides |first2=Peter |date=December 2010 |title=von Willebrand Disease in the Pediatric and Adolescent Population |journal=Journal of Pediatric & Adolescent Gynecology |volume=23 |issue=6 |pages=S3–S10 |doi=10.1016/j.jpag.2010.08.005}} External links
3 : Hematology|Coagulation system|Healing |
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