| 释义 |
- Function
- Interactions
- References
- External links
- Further reading
{{About||the Federal Circuit Court of Appeals|United States Court of Appeals for the Eleventh Circuit|the highway|California State Route 11|the congressional district|California's 11th congressional district}}{{Infobox_gene}}Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene.[1][2] Function Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[2] Interactions CA11 has been shown to interact with RIPK1.[3] References 1. ^{{cite journal | vauthors = Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WW, Tashian RE | title = Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3 | journal = Genomics | volume = 54 | issue = 3 | pages = 484–93 | date = December 1998 | pmid = 9878252 | doi = 10.1006/geno.1998.5585 }}
2. ^1 {{cite web | title = Entrez Gene: CA11 carbonic anhydrase XI| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=770| accessdate = }}
3. ^{{cite journal | vauthors = Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El-Deiry WS, Schütze S, Srinivasula SM | title = CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation | journal = Curr. Biol. | volume = 18 | issue = 9 | pages = 641–9 | date = May 2008 | pmid = 18450452 | pmc = 2587165 | doi = 10.1016/j.cub.2008.04.017 }}
External links Further reading {{refbegin | 2}}- {{cite journal | vauthors = Bellingham J, Gregory-Evans K, Gregory-Evans CY | title = Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3 | journal = Biochem. Biophys. Res. Commun. | volume = 253 | issue = 2 | pages = 364–7 | year = 1998 | pmid = 9878543 | doi = 10.1006/bbrc.1998.9449 }}
- {{cite journal | vauthors = Fujikawa-Adachi K, Nishimori I, Taguchi T, Yuri K, Onishi S | title = cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI | journal = Biochim. Biophys. Acta | volume = 1431 | issue = 2 | pages = 518–24 | year = 1999 | pmid = 10350627 | doi = 10.1016/S0167-4838(99)00067-9 }}
- {{cite journal | vauthors = Okamoto N, Fujikawa-Adachi K, Nishimori I, Taniuchi K, Onishi S | title = cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain | journal = Biochim. Biophys. Acta | volume = 1518 | issue = 3 | pages = 311–6 | year = 2001 | pmid = 11311946 | doi = 10.1016/s0167-4781(01)00193-2 }}
- {{cite journal | vauthors = Taniuchi K, Nishimori I, Takeuchi T, Fujikawa-Adachi K, Ohtsuki Y, Onishi S | title = Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain | journal = Neuroscience | volume = 112 | issue = 1 | pages = 93–9 | year = 2002 | pmid = 12044474 | doi = 10.1016/S0306-4522(02)00066-0 }}
- {{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Res. | volume = 13 | issue = 10 | pages = 2265–70 | year = 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
- {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = J. Proteome Res. | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
{{refend}}{{Carbonic anhydrases}}{{gene-19-stub}} |