| 词条 | Canbisol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451563858 | IUPAC_name = (6aR,9R,10aR)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzo[c]chromene-1,9-diol | image = HU-243_structure.png | width = 200 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 56689-43-1 | ATC_prefix = none | PubChem = 41969 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2105525 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = NZ1ZPC4WSF | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 16736847 | C=24 | H=38 | O=3 | molecular_weight = 374.555 g/mol | smiles = Oc1cc(C(C)(C)CCCCCC)cc(c1C2C3)OC(C)(C)C2CCC3O | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C24H38O3/c1-6-7-8-9-12-23(2,3)16-13-20(26)22-18-15-17(25)10-11-19(18)24(4,5)27-21(22)14-16/h13-14,17-19,25-26H,6-12,15H2,1-5H3/t17?,18-,19-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = UEKGZFCGRQYMRM-MNNMKWMVSA-N }}Canbisol (Nabidrox), is a synthetic cannabinoid derivative that is the dimethylheptyl homologue of 9-nor-9β-hydroxyhexahydrocannabinol (HHC). It is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.1nM at CB1 and 0.2nM at CB2.[1] It is mainly used in scientific research, in receptor binding studies to determine the structure and function of the cannabinoid receptors,[2][3][4] but has been made illegal in some countries due to its possible abuse potential as a cannabinomimetic drug.[5] See also
References1. ^{{cite journal |author=Rhee MH |title=Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase |journal=Journal of Medicinal Chemistry |volume=40 |issue=20 |pages=3228–33 |date=September 1997 |pmid=9379442 |doi=10.1021/jm970126f |url=|display-authors=etal}} {{Cannabinoids}}{{Cannabinoidergics}}{{cannabinoid-stub}}2. ^{{cite journal |author=Rhee MH |title=Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor |journal=Journal of Neurochemistry |volume=75 |issue=6 |pages=2485–91 |date=December 2000 |pmid=11080201 |doi= 10.1046/j.1471-4159.2000.0752485.x|url=|display-authors=etal}} 3. ^{{cite journal |author=Rhee MH |title=Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor |journal=Journal of Veterinary Science |volume=3 |issue=3 |pages=185–91 |date=September 2002 |pmid=12514330 |doi= |url=}} 4. ^{{cite journal |author=Zhang R |title=Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template |journal=Molecular Pharmacology |volume=68 |issue=1 |pages=69–83 |date=July 2005 |pmid=15840841 |doi=10.1124/mol.104.007823 |url=|display-authors=etal}} 5. ^The Misuse of Drugs Act 1971 (Amendment) Order 2009 4 : Cannabinoids|Benzochromenes|Alcohols|Phenols |
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