| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene.[1][2] It is also called 'gustin' because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia.[3][4] Function The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide, though its function in saliva is unknown.[2] It has been suggested that CA VI participates in the maintenance of appropriate pH homeostasis on tooth surfaces as well as in the mucosa of the gastrointestinal canal. References 1. ^{{cite journal | vauthors = White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM | title = Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2 | journal = Cytogenetics and Cell Genetics | volume = 81 | issue = 1 | pages = 60–4 | date = Oct 1998 | pmid = 9691177 | doi = 10.1159/000014989 }}
2. ^1 {{cite web | title = Entrez Gene: CA6 carbonic anhydrase VI| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=765| accessdate = }}
3. ^{{cite journal | vauthors = Henkin RI, Mueller CW, Wolf RO | title = Estimation of zinc concentration of parotid saliva by flameless atomic absorption spectrophotometry in normal subjects and in patients with idiopathic hypogeusia | journal = The Journal of Laboratory and Clinical Medicine | volume = 86 | issue = 1 | pages = 175–80 | date = July 1975 | pmid = 1151138 | url = http://www.translationalres.com/article/0022-2143(75)90022-0/abstract }}
4. ^{{cite journal | vauthors = Henkin RI, Lippoldt RE, Bilstad J, Edelhoch H | title = A zinc protein isolated from human parotid saliva | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 72 | issue = 2 | pages = 488–92 | date = February 1975 | pmid = 1054831 | pmc = 432337 | doi=10.1073/pnas.72.2.488}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Nishimori I, FujikawaAdachi K, Onishi S, Hollingsworth MA | title = Carbonic anhydrase in human pancreas: hypotheses for the pathophysiological roles of CA isozymes | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = | pages = 5–16 | date = June 1999 | pmid = 10415846 | doi = 10.1111/j.1749-6632.1999.tb09505.x }}
- {{cite journal | vauthors = Kivela J, Parkkila S, Parkkila AK, Leinonen J, Rajaniemi H | title = Salivary carbonic anhydrase isoenzyme VI | journal = The Journal of Physiology | volume = 520 Pt 2 | issue = | pages = 315–20 | date = October 1999 | pmid = 10523402 | pmc = 2269599 | doi = 10.1111/j.1469-7793.1999.t01-1-00315.x }}
- {{cite journal | vauthors = Nishimori I, Onishi S | title = Carbonic anhydrase isozymes in the human pancreas | journal = Digestive and Liver Disease | volume = 33 | issue = 1 | pages = 68–74 | year = 2001 | pmid = 11303978 | doi = 10.1016/s1590-8658(01)80138-9 }}
- {{cite journal | vauthors = Breton S | title = The cellular physiology of carbonic anhydrases | journal = JOP | volume = 2 | issue = 4 Suppl | pages = 159–64 | date = July 2001 | pmid = 11875253 | doi = }}
- {{cite journal | vauthors = Aldred P, Fu P, Barrett G, Penschow JD, Wright RD, Coghlan JP, Fernley RT | title = Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry | journal = Biochemistry | volume = 30 | issue = 2 | pages = 569–75 | date = January 1991 | pmid = 1899030 | doi = 10.1021/bi00216a035 }}
- {{cite journal | vauthors = Parkkila S, Kaunisto K, Rajaniemi L, Kumpulainen T, Jokinen K, Rajaniemi H | title = Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands | journal = The Journal of Histochemistry and Cytochemistry | volume = 38 | issue = 7 | pages = 941–7 | date = July 1990 | pmid = 2113069 | doi = 10.1177/38.7.2113069 }}
- {{cite journal | vauthors = Murakami H, Sly WS | title = Purification and characterization of human salivary carbonic anhydrase | journal = The Journal of Biological Chemistry | volume = 262 | issue = 3 | pages = 1382–8 | date = January 1987 | pmid = 2433278 | doi = }}
- {{cite journal | vauthors = Sutherland GR, Baker E, Fernandez KE, Callen DF, Aldred P, Coghlan JP, Wright RD, Fernley RT | title = The gene for human carbonic anhydrase VI(CA6) is on the tip of the short arm of chromosome 1 | journal = Cytogenetics and Cell Genetics | volume = 50 | issue = 2-3 | pages = 149–50 | year = 1989 | pmid = 2505973 | doi = 10.1159/000132746 }}
- {{cite journal | vauthors = Ogawa Y, Hong SS, Toyosawa S, Kuwahara H, Shimazaki M, Yagi T | title = Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II | journal = The Journal of Histochemistry and Cytochemistry | volume = 41 | issue = 3 | pages = 343–51 | date = March 1993 | pmid = 8429198 | doi = 10.1177/41.3.8429198 }}
- {{cite journal | vauthors = Kivelä J, Parkkila S, Waheed A, Parkkila AK, Sly WS, Rajaniemi H | title = Secretory carbonic anhydrase isoenzyme (CA VI) in human serum | journal = Clinical Chemistry | volume = 43 | issue = 12 | pages = 2318–22 | date = December 1997 | pmid = 9439449 | doi = }}
- {{cite journal | vauthors = Thatcher BJ, Doherty AE, Orvisky E, Martin BM, Henkin RI | title = Gustin from human parotid saliva is carbonic anhydrase VI | journal = Biochemical and Biophysical Research Communications | volume = 250 | issue = 3 | pages = 635–41 | date = September 1998 | pmid = 9784398 | doi = 10.1006/bbrc.1998.9356 }}
- {{cite journal | vauthors = Leinonen J, Kivelä J, Parkkila S, Parkkila AK, Rajaniemi H | title = Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle | journal = Caries Research | volume = 33 | issue = 3 | pages = 185–90 | year = 1999 | pmid = 10207193 | doi = 10.1159/000016515 }}
- {{cite journal | vauthors = Redman RS, Peagler FD, Johansson I | title = Immunohistochemical localization of carbonic anhydrases I, II, and VI in the developing rat sublingual and submandibular glands | journal = The Anatomical Record | volume = 258 | issue = 3 | pages = 269–76 | date = March 2000 | pmid = 10705347 | doi = 10.1002/(SICI)1097-0185(20000301)258:3<269::AID-AR6>3.0.CO;2-Y }}
- {{cite journal | vauthors = Leinonen J, Parkkila S, Kaunisto K, Koivunen P, Rajaniemi H | title = Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands | journal = The Journal of Histochemistry and Cytochemistry | volume = 49 | issue = 5 | pages = 657–62 | date = May 2001 | pmid = 11304804 | doi = 10.1177/002215540104900513 }}
- {{cite journal | vauthors = Karhumaa P, Leinonen J, Parkkila S, Kaunisto K, Tapanainen J, Rajaniemi H | title = The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 20 | pages = 11604–8 | date = September 2001 | pmid = 11553764 | pmc = 58776 | doi = 10.1073/pnas.121172598 }}
{{refend}}{{Carbonic anhydrases}}{{gene-1-stub}} |