| 词条 | Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 414048120 | Name = Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone | ImageFile = Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone.svg | ImageSize = 250px | IUPACName = 2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile | OtherNames = | Reference = [1] |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 3213 | InChI = 1/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H | InChIKey = BMZRVOVNUMQTIN-UHFFFAOYAT | SMILES1 = FC(F)(F)Oc1ccc(cc1)N/N=C(\\C#N)C#N | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 457504 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = BMZRVOVNUMQTIN-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo = 370-86-5 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 75458 | PubChem = 3330 | SMILES = C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F | MeSHName = FCCP |Section2={{Chembox Properties | Formula = C10H5F3N4O | MolarMass = 254.16811 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) is an ionophore that is a mobile ion carrier. It is referred to as an uncoupling agent because it disrupts ATP synthesis by transporting hydrogen ions through the mitochondrial membrane before they can be used to provide the energy for oxidative phosphorylation.[2] It is a nitrile and hydrazone. FCCP was first described in 1962 by Heytler.[3] See also
References1. ^[https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3330&loc=ec_rcs FCCP - Compound Summary], PubChem. 2. ^[https://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?mode=&term=FCCP MeSH Descriptor Data], MeSH. 3. ^{{cite journal |author=Heytler, P G |title=A new class of uncoupling agents — Carbonyl cyanide phenylhydrazones |journal=Biochemical and Biophysical Research Communications |volume=7 |issue=4 |pages=272-275 |year=1962 | doi=10.1016/0006-291X(62)90189-4}} 5 : Ionophores|Nitriles|Trifluoromethyl compounds|Uncoupling agents|Hydrazones |
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