“Carboxymethylenebutenolidase”的意思、由来-开放百科全书

词条

Carboxymethylenebutenolidase

释义

Structural studies
References

{{enzyme
| Name = carboxymethylenebutenolidase
| EC_number = 3.1.1.45
| CAS_number = 76689-22-0
| IUBMB_EC_number = 3/1/1/45
| GO_code = 0008806
| image =
| width =
| caption =
}}

In enzymology, a carboxymethylenebutenolidase ({{EC number|3.1.1.45}}, also known as CMBL and dienelactone hydrolase) is an enzyme that catalyzes the chemical reaction

4-carboxymethylenebut-2-en-4-olide + H₂O 4-oxohex-2-enedioate

Thus, the two substrates of this enzyme are 4-carboxymethylenebut-2-en-4-olide and H₂O, whereas its product is 4-oxohex-2-enedioate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 4-carboxymethylenebut-2-en-4-olide lactonohydrolase. Other names in common use include maleylacetate enol-lactonase, dienelactone hydrolase, and carboxymethylene butenolide hydrolase. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1DIN}}, {{PDB link|1GGV}}, {{PDB link|1ZI6}}, {{PDB link|1ZI8}}, {{PDB link|1ZI9}}, {{PDB link|1ZIC}}, {{PDB link|1ZIX}}, {{PDB link|1ZIY}}, {{PDB link|1ZJ4}}, and {{PDB link|1ZJ5}}.

References

{{cite journal |vauthors=Schmidt E, Knackmuss HJ | date = 1980 | title = Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid | journal = Biochem. J. | volume = 192 | pages = 339–47 | pmid = 7305906 | issue = 1 | pmc = 1162339 }}

2 : EC 3.1.1|Enzymes of known structure

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