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词条 CARD10
释义

  1. Function

  2. Interactions

  3. References

  4. External links

  5. Further reading

{{Infobox_gene}}Caspase recruitment domain-containing protein 10 is an enzyme that in humans is encoded by the CARD10 gene.[1][2][3]

Function

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM][3]

Interactions

CARD10 has been shown to interact with BCL10.[4]

References

1. ^{{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–9 | date = June 2001 | pmid = 11259443 | pmc = | doi = 10.1074/jbc.M102488200 }}
2. ^{{cite journal | vauthors = Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J | title = Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation | journal = FEBS Lett. | volume = 496 | issue = 2-3 | pages = 121–7 | date = May 2001 | pmid = 11356195 | pmc = | doi = 10.1016/S0014-5793(01)02414-0 }}
3. ^1 {{cite web | title = Entrez Gene: CARD10 caspase recruitment domain family, member 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29775| accessdate = }}
4. ^{{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–9 | date = June 2001 | pmid = 11259443 | doi = 10.1074/jbc.M102488200 }}

External links

  • {{UCSC gene info|CARD10}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
  • {{cite journal | vauthors = McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Núñez G | title = Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction | journal = J. Biol. Chem. | volume = 276 | issue = 33 | pages = 30589–97 | year = 2001 | pmid = 11387339 | doi = 10.1074/jbc.M103824200 }}
  • {{cite journal | vauthors = Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ | title = The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes | journal = Mol. Cell | volume = 14 | issue = 3 | pages = 289–301 | year = 2004 | pmid = 15125833 | doi = 10.1016/S1097-2765(04)00236-9 }}
  • {{cite journal | vauthors = Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P | title = Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator | journal = J. Biol. Chem. | volume = 279 | issue = 33 | pages = 34323–31 | year = 2004 | pmid = 15184390 | doi = 10.1074/jbc.M402244200 }}
  • {{cite journal | vauthors = McAllister-Lucas LM, Ruland J, Siu K, Jin X, Gu S, Kim DS, Kuffa P, Kohrt D, Mak TW, Nuñez G, Lucas PC | title = CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 1 | pages = 139–44 | year = 2007 | pmid = 17101977 | pmc = 1766317 | doi = 10.1073/pnas.0601947103 }}
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