“CARD11”的意思、由来-开放百科全书

Function

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activates NF-kappaB and induces the phosphorylation of BCL10.^[3]

References

1. ^{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82 | date = Apr 2001 | pmid = 11278692 | pmc = | doi = 10.1074/jbc.M010512200 }}
2. ^{{cite journal | vauthors = Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J | title = Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation | journal = FEBS Lett. | volume = 496 | issue = 2-3 | pages = 121–7 | date = May 2001 | pmid = 11356195 | pmc = | doi = 10.1016/S0014-5793(01)02414-0 }}
3. ^¹{{cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = }}
4. ^{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82 | date = April 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 }}

Further reading

{{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}

{{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}

{{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–9 | year = 2001 | pmid = 11259443 | doi = 10.1074/jbc.M102488200 }}

{{cite journal | vauthors = Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X | title = A requirement for CARMA1 in TCR-induced NF-kappa B activation | journal = Nat. Immunol. | volume = 3 | issue = 9 | pages = 830–5 | year = 2002 | pmid = 12154356 | doi = 10.1038/ni824 }}

{{cite journal | vauthors = Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M | title = CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation | journal = Nat. Immunol. | volume = 3 | issue = 9 | pages = 836–43 | year = 2002 | pmid = 12154360 | doi = 10.1038/ni830 }}

{{cite journal | vauthors = Pomerantz JL, Denny EM, Baltimore D | title = CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex | journal = EMBO J. | volume = 21 | issue = 19 | pages = 5184–94 | year = 2002 | pmid = 12356734 | pmc = 129028 | doi = 10.1093/emboj/cdf505 }}

{{cite journal | vauthors = Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X | title = CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1 | journal = Mol. Cell. Biol. | volume = 24 | issue = 1 | pages = 164–71 | year = 2004 | pmid = 14673152 | pmc = 303359 | doi = 10.1128/MCB.24.1.164-171.2003 }}

{{cite journal | vauthors = Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P | title = Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator | journal = J. Biol. Chem. | volume = 279 | issue = 33 | pages = 34323–31 | year = 2004 | pmid = 15184390 | doi = 10.1074/jbc.M402244200 }}

{{cite journal | vauthors = Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S | title = PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation | journal = Science | volume = 308 | issue = 5718 | pages = 114–8 | year = 2005 | pmid = 15802604 | doi = 10.1126/science.1107107 }}

{{cite journal | vauthors = Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T | title = PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1 | journal = J. Exp. Med. | volume = 202 | issue = 10 | pages = 1423–31 | year = 2005 | pmid = 16301747 | pmc = 2212994 | doi = 10.1084/jem.20051591 }}

{{cite journal | vauthors = Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ | title = Phosphorylation of the CARMA1 linker controls NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 561–74 | year = 2005 | pmid = 16356855 | doi = 10.1016/j.immuni.2005.09.014 }}

{{cite journal | vauthors = Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X | title = Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 575–85 | year = 2005 | pmid = 16356856 | doi = 10.1016/j.immuni.2005.10.007 }}

{{cite journal | vauthors = Narayan P, Holt B, Tosti R, Kane LP | title = CARMA1 is required for Akt-mediated NF-kappaB activation in T cells | journal = Mol. Cell. Biol. | volume = 26 | issue = 6 | pages = 2327–36 | year = 2006 | pmid = 16508008 | pmc = 1430296 | doi = 10.1128/MCB.26.6.2327-2336.2006 }}

{{cite journal | vauthors = Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R | title = Nore1B regulates TCR signaling via Ras and Carma1 | journal = Cell. Signal. | volume = 18 | issue = 10 | pages = 1647–54 | year = 2006 | pmid = 16520020 | pmc = 3204664 | doi = 10.1016/j.cellsig.2006.01.015 }}

{{cite journal | vauthors = Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ | title = Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation | journal = Mol. Cell. Biol. | volume = 26 | issue = 14 | pages = 5497–508 | year = 2006 | pmid = 16809782 | pmc = 1592706 | doi = 10.1128/MCB.02469-05 }}

1 : Proteins

Function

Interactions

References

External links

Further reading