| 词条 | Caroline Dean |
| 释义 |
| name = Dame Caroline Dean | native_name = | native_name_lang = | image = Caroline Dean journal pgen 1003593 g001.png | image_size = 200px | alt = | caption = | birth_date = {{Birth date and age|df=y|1957|4|2}}[1] | birth_place = | death_date = | death_place = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = | nationality = | fields = {{Plainlist|
| workplaces = {{Plainlist|
| alma_mater = University of York (BSc, DPhil)[2] | thesis_title = Investigations of genome expression in young wheat leaves | thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.331606 | thesis_year = 1983 | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = {{Plainlist|
| influences = | influenced = | awards = {{Plainlist|
| signature = | signature_alt = | website = {{URL|http://www.jic.ac.uk/staff/caroline-dean}} | footnotes = | spouse = {{marriage|Jonathan D. G. Jones|1991}}[1] | children = one son, one daughter[1][6] }} Dame Caroline Dean, OBE, FRS[7] (born 2 April 1957) is a British plant scientist working at the John Innes Centre. She is focused on understanding the molecular controls used by plants to seasonally judge when to flower. She is specifically interested in vernalisation — the acceleration of flowering in plants by exposure to periods of prolonged cold.[8][9][10][11][12][13][14][15].. EducationDean was educated at the University of York, where she was awarded a Bachelor of Arts degree in Biology in 1978 and a Ph.D. in Biology[2] in 1982.[16][17] ResearchDean's research has been funded by the Biotechnology and Biological Sciences Research Council[18] European Research Council, EU-Marie Curie and EMBO and focuses on research on gene regulation and the intersection of chromatin, transcription and non-coding RNAs. Her goal is to understand the chromatin dynamics that enable switching between epigenetic states and quantitative regulation of gene expression. This mechanistic analysis is focused on one gene encoding the floral repressor FLC. Epigenetic switching and quantitative regulation of FLC play a central role in seasonal timing in plants. This acceleration of flowering by prolonged cold is a classic epigenetic process called vernalisation. FLC regulation involves an antisense-mediated chromatin mechanism that coordinately influences transcription initiation and elongation. As plants overwinter FLC expression is then epigenetically silenced through a cold-induced, cis-based, Polycomb switching mechanism. The group are mechanistically dissecting these conserved chromatin mechanisms and investigating how they have been modulated during adaptation. She uses Arabidopsis as a reference to establish the regulatory hierarchy and then use this information to translate into other species. She was a pioneer in Arabidopsis becoming a key model organism in plant science. [19] Awards1993 - 2002 Honorary Research Fellow, School of Biological Sciences, University of East Anglia Since 1999 -Member of the European Molecular Biology Organization (EMBO) 2004 - Dean was appointed office of the Dame Commander of the Order of the British Empire (DBE) and a Fellow of the Royal Society. 2007 - she was awarded the Genetics Society Medal 2008 - the United States National Academy of Sciences elected her a foreign fellow. Her nomination for the Royal Society reads: {{centered pull quote|Dean has made outstanding contributions in the study of developmental timing in plants. Her work has revealed the mechanism by which plants remember they have experienced winter, demonstrated novel RNA processing mechanisms controlling flowering and determined the molecular basis of natural variation in Arabidopsis flowering time. Her discoveries have broad significance in the fields of epigenetics, post-transcriptional regulation and molecular evolution. Dean has also made a massive contribution to the development of Arabidopsis as a model, establishing resources for genetic mapping and insertional mutagenesis, and providing physical maps that underpinned the sequencing of the genome.[7]}} Since 2008 she has been a member of the German National Academy of Sciences Leopoldina. 2015 - FEBS EMBO Women in Science Award. She was appointed Dame Commander of the Order of the British Empire (DBE) in the 2016 Birthday Honours for services to plant science research and women in science.[20] Dean was awarded with the Darwin Medal 2016 by the Royal Society, citing: {{centered pull quote|For her work addressing fundamental questions in the perception of temperature cues and how modifications in epigenetic mechanisms play an important role in adaptation.[5]}} In 2018 she was awarded the L'Oréal-UNESCO For Women in Science Award. Personal lifeDean is married to Jonathan D. G. Jones and has one son and one daughter.[1][6] References1. ^1 2 3 {{Who's Who | surname = DEAN | othernames = Caroline | id = U10000433 | volume = 2015 | edition = online Oxford University Press}} {{subscription required}} {{FRS 2004}}{{Authority control}}{{DEFAULTSORT:Dean, Caroline}}2. ^1 {{cite thesis |degree=PhD |first=Caroline|last=Dean |title=Investigations of genome expression in young wheat leaves |publisher=University of York |date=1983 |url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.331606|authorlink=Caroline Dean}} 3. ^{{Cite journal | last1 = Meinke | first1 = D. W. | last2 = Cherry | first2 = J. M. | last3 = Dean | first3 = C. | last4 = Rounsley | first4 = S. D. | last5 = Koornneef | first5 = M. | title = Arabidopsis thaliana: A Model Plant for Genome Analysis | doi = 10.1126/science.282.5389.662 | journal = Science | volume = 282 | issue = 5389 | pages = 662, 679–82 | year = 1998 | pmid = 9784120| pmc = |bibcode = 1998Sci...282..662M | citeseerx = 10.1.1.462.4735 }} 4. ^{{cite web |url=http://www.jic.ac.uk/corporate/media-and-public/current-releases/080501CarolineDean.htm |title=John Innes Centre scientist receives top international honour |date=2008 |publisher=John Innes Centre |archivedate=2011-08-15 |archiveurl=https://web.archive.org/web/20110815013946/http://www.jic.ac.uk/corporate/media-and-public/current-releases/080501CarolineDean.htm}} 5. ^1 {{cite web | url=https://docs.google.com/spreadsheets/d/1dsunM9ukGLgaW3HdG9cvJ_QKd7pWjGI0qi_fCb1ROD4/pubhtml?gid=216486814&single=true | title=Award winners : Darwin Medal | publisher=The Royal Society | accessdate=2016-07-21}} 6. ^1 {{Cite journal | pmid = 22405408| pmc = 3439960| year = 2012| author1 = Dean| first1 = Caroline| authorlink1 = Caroline Dean| title = Women in science| journal = Genome Biology| volume = 13| issue = 3| pages = 148| last2 = Osborn| first2 = Mary| authorlink2 = Mary Osborn| last3 = Oshlack| first3 = Alicia| authorlink3 = Alicia Oshlack| last4 = Thornton| first4 = Janet| authorlink4 = Janet Thornton| doi = 10.1186/gb4005}} 7. ^1 2 {{cite web |url=https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F2004%2F15%27) |title=EC/2004/15: Dean, Caroline |publisher=The Royal Society |archivedate=2 February 2015 |archiveurl=https://www.webcitation.org/6W2WFVe11?url=https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=%28RefNo%3D%3D%27EC%2F2004%2F15%27%29 |location=London |deadurl=yes |df=dmy-all }} 8. ^{{Cite journal | last1 = Gitschier | first1 = J. | title = How Cool is That: An Interview with Caroline Dean | doi = 10.1371/journal.pgen.1003593 | journal = PLoS Genetics | volume = 9 | issue = 6 | pages = e1003593 | year = 2013 | pmid = 23825965 | pmc =3694836 }} 9. ^{{Cite journal| last1 = Vaeck | first1 = M.| last2 = Reynaerts | first2 = A.| last3 = Höfte | first3 = H.| last4 = Jansens | first4 = S.| last5 = De Beuckeleer | first5 = M.| last6 = Dean | first6 = C.| authorlink6 = Caroline Dean| last7 = Zabeau | first7 = M.| last8 = Montagu | first8 = M. V.| last9 = Leemans | first9 = J.| title = Transgenic plants protected from insect attack| journal = Nature| volume = 328| issue = 6125| pages = 33–37| year = 1987| doi = 10.1038/328033a0|bibcode = 1987Natur.328...33V }} 10. ^{{Cite journal | last1 = Simpson | first1 = G. G. | last2 = Dean | first2 = C. | authorlink2 = Caroline Dean| title = Arabidopsis, the Rosetta Stone of Flowering Time? | doi = 10.1126/science.296.5566.285 | journal = Science | volume = 296 | issue = 5566 | pages = 285–289 | year = 2002 | pmid = 11951029| pmc = |bibcode = 2002Sci...296..285S }} 11. ^{{Scopus|id=16235942500}} 12. ^{{Cite journal | doi = 10.1101/gad.9.14.1797 | last1 = Sundaresan | first1 = V. | last2 = Springer | first2 = P. | last3 = Volpe | first3 = T. | last4 = Haward | first4 = S. | last5 = Jones | first5 = J. D. | last6 = Dean | first6 = C. | last7 = Ma | first7 = H. | last8 = Martienssen | first8 = R. | title = Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements | journal = Genes & Development | volume = 9 | issue = 14 | pages = 1797–1810 | year = 1995 | pmid = 7622040}} 13. ^{{Cite journal | last1 = Johanson | first1 = U. | last2 = West | first2 = J. | last3 = Lister | first3 = C. | last4 = Michaels | first4 = S. | last5 = Amasino | first5 = R. | last6 = Dean | first6 = C. | title = Molecular Analysis of FRIGIDA, a Major Determinant of Natural Variation in Arabidopsis Flowering Time | doi = 10.1126/science.290.5490.344 | journal = Science | volume = 290 | issue = 5490 | pages = 344–347 | year = 2000 | pmid = 11030654| pmc = |bibcode = 2000Sci...290..344J }} 14. ^{{Cite journal | last1 = Lister | first1 = C. | last2 = Dean | first2 = C. | authorlink2 = Caroline Dean| doi = 10.1046/j.1365-313X.1993.04040745.x | title = Recombinant inbred lines for mapping RFLP and phenotypic markers in Arabidopsis thaliana | journal = The Plant Journal | volume = 4 | issue = 4 | pages = 745–750 | year = 1993 | pmid = | pmc = }} 15. ^{{AcademicSearch|23428253}} 16. ^1 {{Cite journal | last1 = Bastow | first1 = R. | last2 = Mylne | first2 = J. S. | last3 = Lister | first3 = C. | last4 = Lippman | first4 = Z. | last5 = Martienssen | first5 = R. A. | last6 = Dean | first6 = C. | authorlink6 = Caroline Dean| doi = 10.1038/nature02269 | title = Vernalization requires epigenetic silencing of FLC by histone methylation | journal = Nature | volume = 427 | issue = 6970 | pages = 164–167 | year = 2004 | pmid = 14712277| pmc = |bibcode = 2004Natur.427..164B }} 17. ^{{cite web|url=http://www.jic.ac.uk/profile/caroline-dean.asp |title=Caroline Dean, Cell & Developmental Biology |format= |website= |archivedate=2013-07-14 |archiveurl=https://www.webcitation.org/6I6RwwNPQ?url=http://www.jic.ac.uk/profile/caroline-dean.asp |deadurl=yes |df= |date=2018-11-23 }} 18. ^{{cite web |url=http://gtr.rcuk.ac.uk/person/F2DDB4A0-400A-4441-88F3-5C9389AF6784 |title=UK Government Grants awarded to Caroline Dean |format= |website= |accessdate=}}, via Research Councils UK 19. ^{{Cite web|url=http://dev.biologists.org/content/develop/142/16/2725.full.pdf|title=Caroline Interview - The Company of Biologists|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}} 20. ^{{London Gazette|issue=61608|supp=y|page=B8|date=11 June 2016}} 15 : Female Fellows of the Royal Society|Members of the United States National Academy of Sciences|Living people|20th-century British botanists|21st-century British botanists|British women biologists|Dames Commander of the Order of the British Empire|Place of birth missing (living people)|Alumni of the University of York|Academics of the University of York|Academics of the University of East Anglia|Members of the European Molecular Biology Organization|1957 births|Fellows of the Royal Society|L'Oréal-UNESCO Awards for Women in Science laureates |
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