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词条 Cathepsin L2
释义

  1. Clinical significance

  2. References

  3. External links

  4. Further reading

{{Redirect|CTSV|the car|Cadillac CTS-V}}{{Use dmy dates|date=July 2013}}{{Infobox_gene}}Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene.[1]

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Clinical significance

Cathepsin L2 may play a role in the pathogenesis of keratoconus.[2]

References

1. ^{{cite web | title = Entrez Gene: CTSL2 cathepsin L2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1515| accessdate = }}
2. ^{{cite journal | vauthors = Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ | year = 2005 | title = Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder | url = | journal = Invest. Ophthal. Vis. Sci. | volume = 46 | issue = 3| pages = 823–832 | doi = 10.1167/iovs.04-0549 | pmid = 15728537 }}

External links

  • The MEROPS online database for peptidases and their inhibitors: C01.009

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Santamaría I, Velasco G, Cazorla M |title=Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. |journal=Cancer Res. |volume=58 |issue= 8 |pages= 1624–30 |year= 1998 |pmid= 9563472 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Adachi W, Kawamoto S, Ohno I |title=Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 10 |pages= 1789–96 |year= 1998 |pmid= 9727401 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Brömme D, Li Z, Barnes M, Mehler E |title=Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. |journal=Biochemistry |volume=38 |issue= 8 |pages= 2377–85 |year= 1999 |pmid= 10029531 |doi= 10.1021/bi982175f }}
  • {{cite journal | vauthors=Itoh R, Kawamoto S, Adachi W |title=Genomic organization and chromosomal localization of the human cathepsin L2 gene. |journal=DNA Res. |volume=6 |issue= 2 |pages= 137–40 |year= 1999 |pmid= 10382972 |doi=10.1093/dnares/6.2.137 |display-authors=etal}}
  • {{cite journal | vauthors=Somoza JR, Zhan H, Bowman KK |title=Crystal structure of human cathepsin V. |journal=Biochemistry |volume=39 |issue= 41 |pages= 12543–51 |year= 2000 |pmid= 11027133 |doi=10.1021/bi000951p |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal}}
  • {{cite journal | vauthors=Bernard D, Méhul B, Thomas-Collignon A |title=Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2. |journal=J. Invest. Dermatol. |volume=120 |issue= 4 |pages= 592–600 |year= 2003 |pmid= 12648222 |doi= 10.1046/j.1523-1747.2003.12086.x |display-authors=etal}}
  • {{cite journal | vauthors=Tolosa E, Li W, Yasuda Y |title=Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. |journal=J. Clin. Invest. |volume=112 |issue= 4 |pages= 517–26 |year= 2003 |pmid= 12925692 |doi= 10.1172/JCI18028 |pmc=171390|display-authors=etal}}
  • {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |pmc=403697|display-authors=etal}}
  • {{cite journal | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 |pmc=2734081|display-authors=etal}}
  • {{cite journal | vauthors=Yasuda Y, Li Z, Greenbaum D |title=Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36761–70 |year= 2004 |pmid= 15192101 |doi= 10.1074/jbc.M403986200 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
  • {{cite journal | vauthors=Hagemann S, Günther T, Dennemärker J |title=The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. |journal=Eur. J. Cell Biol. |volume=83 |issue= 11–12 |pages= 775–80 |year= 2005 |pmid= 15679121 |doi=10.1078/0171-9335-00404 |display-authors=etal}}
  • {{cite journal | vauthors=Cheng T, Hitomi K, van Vlijmen-Willems IM |title=Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. |journal=J. Biol. Chem. |volume=281 |issue= 23 |pages= 15893–9 |year= 2006 |pmid= 16565075 |doi= 10.1074/jbc.M600694200 |display-authors=etal}}
  • {{cite journal | vauthors=Burden RE, Snoddy P, Jefferies CA |title=Inhibition of cathepsin L-like proteases by cathepsin V propeptide. |journal=Biol. Chem. |volume=388 |issue= 5 |pages= 541–5 |year= 2007 |pmid= 17516850 |doi= 10.1515/BC.2007.053 |display-authors=etal}}
  • {{cite journal | vauthors=Viken MK, Sollid HD, Joner G |title=Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis. |journal=Hum. Immunol. |volume=68 |issue= 9 |pages= 748–55 |year= 2007 |pmid= 17869649 |doi= 10.1016/j.humimm.2007.05.009 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=1515}}{{Cysteine proteases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-9-stub}}

2 : Peptidase|EC 3.4.22
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