| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Cathepsin W is a protein that in humans is encoded by the CTSW gene.[1][2][3]The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[3] References1. ^{{cite journal | vauthors = Linnevers C, Smeekens SP, Bromme D | title = Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes | journal = FEBS Lett | volume = 405 | issue = 3 | pages = 253–9 |date=May 1997 | pmid = 9108299 | pmc = | doi = 10.1016/S0014-5793(97)00118-X}}
2. ^{{cite journal | vauthors = Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D | title = Genomic structure, chromosomal localization, and expression of human cathepsin W | journal = Biochem Biophys Res Commun | volume = 248 | issue = 2 | pages = 255–61 |date=Aug 1998 | pmid = 9675123 | pmc = | doi = 10.1006/bbrc.1998.8954 }}
3. ^1 {{cite web | title = Entrez Gene: CTSW cathepsin W| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1521| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
- {{cite journal | vauthors=Meinhardt C, Peitz U, Treiber G |title=Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 4 |pages= 975–80 |year= 2004 |pmid= 15358123 |doi= 10.1016/j.bbrc.2004.07.056 |display-authors=etal}}
- {{cite journal | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 |pmc=2286551}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal}}
- {{cite journal | vauthors=Buhling F, Kellner U, Guenther D |title=Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract. |journal=Biol. Chem. |volume=383 |issue= 7-8 |pages= 1285–9 |year= 2003 |pmid= 12437118 |doi=10.1515/BC.2002.144 |display-authors=etal}}
- {{cite journal | vauthors=Wex T, Bühling F, Wex H |title=Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. |journal=J. Immunol. |volume=167 |issue= 4 |pages= 2172–8 |year= 2001 |pmid= 11490002 |doi= 10.4049/jimmunol.167.4.2172|display-authors=etal}}
- {{cite journal | vauthors=Wex T, Levy B, Wex H, Brömme D |title=Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases. |journal=Adv. Exp. Med. Biol. |volume=477 |issue= |pages= 271–80 |year= 2000 |pmid= 10849754 |doi=10.1007/0-306-46826-3_29 }}
- {{cite journal | vauthors=Brinkworth RI, Tort JF, Brindley PJ, Dalton JP |title=Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 3 |pages= 373–84 |year= 2000 |pmid= 10716634 |doi=10.1016/S1357-2725(99)00129-6 }}
- {{cite journal | vauthors=Wex T, Levy B, Wex H, Brömme D |title=Human cathepsins F and W: A new subgroup of cathepsins. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 2 |pages= 401–7 |year= 1999 |pmid= 10362521 |doi= 10.1006/bbrc.1999.0700 }}
- {{cite journal | vauthors=Brown J, Matutes E, Singleton A |title=Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. |journal=Leukemia |volume=12 |issue= 11 |pages= 1771–81 |year= 1998 |pmid= 9823953 |doi=10.1038/sj.leu.2401164 |display-authors=etal}}
{{refend}}External links- The MEROPS online database for peptidases and their inhibitors: C01.037
{{Cysteine proteases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-11-stub}} 3 : Peptidase|EC 3.4.22|Cathepsins |