CB-2 may refer to:

• USS Guam (CB-2)
• Cannabinoid receptor type 2

• List of BBC properties
• List of BBC Radio Sherlock Holmes Dramatisations
• List of BBC Radio Sherlock Holmes dramatisations
• List of BBC Sports Personality of the Year awards
• List of BBC Sports Personality of the Year Awards
• List of BBSes
• List of bbt Episodes
• List of BC Lions head coaches
• List of BC Lions seasons
• List of B codes for MeSH
• List of B.C. Rich guitars
• List of BCS National Championship broadcasters
• List of BDO darts players who joined the PDC before returning
• List of BDSM topics
• List of beaches in Bahrain
• List of beaches in Bangladesh
• List of beaches in Delaware
• List of beaches in Hawaii (island)
• List of beaches in India
• List of beaches in Kauai
• List of beaches in Maui
• List of beaches in Menorca
• List of beaches in Niihau
• List of beaches in Oahu
• List of beaches in Oregon