“CBFA2T3”的意思、由来-开放百科全书

Function

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.^[2]

References

1. ^{{cite journal | vauthors = Calabi F, Cilli V | title = CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family | journal = Genomics | volume = 52 | issue = 3 | pages = 332–41 | date = Dec 1998 | pmid = 9790752 | pmc = | doi = 10.1006/geno.1998.5429 }}
2. ^¹{{cite web | title = Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=863| accessdate = }}
3. ^¹²{{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | date = Sep 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}
4. ^¹{{cite journal | vauthors = Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW | title = ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain | journal = Mol. Cell. Biol. | volume = 21 | issue = 19 | pages = 6470–83 | date = Oct 2001 | pmid = 11533236 | pmc = 99794 | doi = 10.1128/mcb.21.19.6470-6483.2001}}
5. ^{{cite journal | vauthors = Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW | title = Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes | journal = J. Immunol. | volume = 168 | issue = 4 | pages = 1590–9 | date = Feb 2002 | pmid = 11823486 | doi = 10.4049/jimmunol.168.4.1590}}
6. ^{{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | date = Dec 2003 | pmid = 14703694 | doi = 10.1046/j.0902-4441.2003.00166.x}}
7. ^¹²{{cite journal | vauthors = Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T | title = ETO2 coordinates cellular proliferation and differentiation during erythropoiesis | journal = EMBO J. | volume = 25 | issue = 2 | pages = 357–66 | date = Jan 2006 | pmid = 16407974 | pmc = 1383517 | doi = 10.1038/sj.emboj.7600934 }}

Further reading

{{cite journal | vauthors = Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M | title = The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 846–58 | year = 1998 | pmid = 9447981 | pmc = 108796 | doi = }}

{{cite journal | vauthors = Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M | title = The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. | journal = Blood | volume = 91 | issue = 11 | pages = 4028–37 | year = 1998 | pmid = 9596646 | doi = }}

{{cite journal | vauthors = Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW | title = Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. | journal = J. Immunol. | volume = 168 | issue = 4 | pages = 1590–9 | year = 2002 | pmid = 11823486 | doi = 10.4049/jimmunol.168.4.1590 }}

{{cite journal | vauthors = Kondoh K, Nakata Y, Furuta T, Hosoda F, Gamou T, Kurosawa Y, Kinoshita A, Ohki M, Tomita Y, Mori T | title = A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. | journal = Leuk. Lymphoma | volume = 43 | issue = 2 | pages = 415–20 | year = 2003 | pmid = 11999578 | doi = 10.1080/10428190290006242 }}

{{cite journal | vauthors = Kochetkova M, McKenzie OL, Bais AJ, Martin JM, Secker GA, Seshadri R, Powell JA, Hinze SJ, Gardner AE, Spendlove HE, O'Callaghan NJ, Cleton-Jansen AM, Cornelisse C, Whitmore SA, Crawford J, Kremmidiotis G, Sutherland GR, Callen DF | title = CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. | journal = Cancer Res. | volume = 62 | issue = 16 | pages = 4599–604 | year = 2002 | pmid = 12183414 | doi = }}

{{cite journal | vauthors = Powell JA, Gardner AE, Bais AJ, Hinze SJ, Baker E, Whitmore S, Crawford J, Kochetkova M, Spendlove HE, Doggett NA, Sutherland GR, Callen DF, Kremmidiotis G | title = Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. | journal = Genomics | volume = 80 | issue = 3 | pages = 303–10 | year = 2003 | pmid = 12213200 | doi = 10.1006/geno.2002.6828 }}

{{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | year = 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}

{{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | year = 2004 | pmid = 14703694 | doi = 10.1046/j.0902-4441.2003.00166.x }}

{{cite journal | vauthors = Ibañez V, Sharma A, Buonamici S, Verma A, Kalakonda S, Wang J, Kadkol S, Saunthararajah Y | title = AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. | journal = Cancer Res. | volume = 64 | issue = 13 | pages = 4547–54 | year = 2004 | pmid = 15231665 | doi = 10.1158/0008-5472.CAN-03-3689 }}

{{cite journal | vauthors = Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF | title = ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. | journal = Mol. Cancer Res. | volume = 4 | issue = 9 | pages = 655–65 | year = 2006 | pmid = 16966434 | doi = 10.1158/1541-7786.MCR-05-0249 }}

Function

Interactions

References

Further reading

External links