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词条 CCR3 (gene)
释义

  1. Function

  2. See also

  3. Interactions

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.[1]

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

Function

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils,[2] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.[1]

See also

  • Cluster of differentiation

Interactions

CCR3 (gene) has been shown to interact with CCL5.[3][4][5]

References

1. ^1 {{cite web | title = Entrez Gene: CCR3 chemokine (C-C motif) receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1232| accessdate = }}
2. ^•Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.
3. ^{{cite journal | vauthors = Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR | title = Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils | journal = J. Exp. Med. | volume = 183 | issue = 6 | pages = 2437–48 | pmid = 8676064 | pmc = 2192612 | doi = 10.1084/jem.183.6.2437 }}
4. ^{{cite journal | vauthors = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2349–54 | date = May 1996 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 }}
5. ^{{cite journal | vauthors = Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J | title = Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils | journal = Eur. J. Immunol. | volume = 31 | issue = 7 | pages = 2170–8 | date = July 2001 | pmid = 11449371 | doi = 10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d }}

Further reading

{{refbegin|35em}}
  • {{cite journal | vauthors = Choe H, Martin KA, Farzan M, Sodroski J, Gerard NP, Gerard C | title = Structural interactions between chemokine receptors, gp120 Env and CD4 | journal = Semin. Immunol. | volume = 10 | issue = 3 | pages = 249–57 | year = 1998 | pmid = 9653051 | doi = 10.1006/smim.1998.0127 }}
  • {{cite journal | vauthors = Marone G, Florio G, Petraroli A, de Paulis A | title = Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection | journal = J. Allergy Clin. Immunol. | volume = 107 | issue = 1 | pages = 22–30 | year = 2001 | pmid = 11149986 | doi = 10.1067/mai.2001.111589 }}
  • {{cite journal | vauthors = Marone G, Florio G, Triggiani M, Petraroli A, de Paulis A | title = Mechanisms of IgE elevation in HIV-1 infection | journal = Crit. Rev. Immunol. | volume = 20 | issue = 6 | pages = 477–96 | year = 2001 | pmid = 11396683 | doi = 10.1615/critrevimmunol.v20.i6.40 }}
  • {{cite journal | vauthors = Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM | title = HIV-1 infection and chemokine receptor modulation | journal = Curr. HIV Res. | volume = 2 | issue = 1 | pages = 39–50 | year = 2004 | pmid = 15053339 | doi = 10.2174/1570162043484997 }}
  • {{cite journal | vauthors = Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C | title = Molecular characterization of two murine eosinophil beta chemokine receptors | journal = J. Immunol. | volume = 155 | issue = 11 | pages = 5299–305 | year = 1995 | pmid = 7594543 | doi = }}
  • {{cite journal | vauthors = Combadiere C, Ahuja SK, Murphy PM | title = Cloning and functional expression of a human eosinophil CC chemokine receptor | journal = J. Biol. Chem. | volume = 270 | issue = 28 | pages = 16491–4 | year = 1995 | pmid = 7622448 | doi = 10.1074/jbc.270.28.16491 }}
  • {{cite journal | vauthors = Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR | title = Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils | journal = J. Clin. Invest. | volume = 97 | issue = 3 | pages = 604–12 | year = 1996 | pmid = 8609214 | pmc = 507095 | doi = 10.1172/JCI118456 }}
  • {{cite journal | vauthors = Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O | title = Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3 | journal = J. Biol. Chem. | volume = 271 | issue = 13 | pages = 7725–30 | year = 1996 | pmid = 8631813 | doi = 10.1074/jbc.271.13.7725 }}
  • {{cite journal | vauthors = Combadiere C, Ahuja SK, Murphy PM | title = Cloning and functional expression of a human eosinophil CC chemokine receptor | journal = J. Biol. Chem. | volume = 271 | issue = 18 | pages = 11034 | year = 1996 | pmid = 8631926 | doi = }}
  • {{cite journal | vauthors = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2349–54 | year = 1996 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 }}
  • {{cite journal | vauthors = Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J | title = The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates | journal = Cell | volume = 85 | issue = 7 | pages = 1135–48 | year = 1996 | pmid = 8674119 | doi = 10.1016/S0092-8674(00)81313-6 }}
  • {{cite journal | vauthors = Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR | title = Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils | journal = J. Exp. Med. | volume = 183 | issue = 6 | pages = 2437–48 | year = 1996 | pmid = 8676064 | pmc = 2192612 | doi = 10.1084/jem.183.6.2437 }}
  • {{cite journal | vauthors = Samson M, Soularue P, Vassart G, Parmentier M | title = The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3 | journal = Genomics | volume = 36 | issue = 3 | pages = 522–6 | year = 1997 | pmid = 8884276 | doi = 10.1006/geno.1996.0498 }}
  • {{cite journal | vauthors = Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, Mackay CR | title = Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody | journal = J. Clin. Invest. | volume = 99 | issue = 2 | pages = 178–84 | year = 1997 | pmid = 9005985 | pmc = 507784 | doi = 10.1172/JCI119145 }}
  • {{cite journal | vauthors = He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D | title = CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia | journal = Nature | volume = 385 | issue = 6617 | pages = 645–9 | year = 1997 | pmid = 9024664 | doi = 10.1038/385645a0 }}
  • {{cite journal | vauthors = Daugherty BL, Springer MS | title = The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21 | journal = Genomics | volume = 41 | issue = 2 | pages = 294–5 | year = 1997 | pmid = 9143512 | doi = 10.1006/geno.1997.4626 }}
  • {{cite journal | vauthors = Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, Baggiolini M | title = Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes | journal = J. Exp. Med. | volume = 185 | issue = 12 | pages = 2171–6 | year = 1997 | pmid = 9182688 | pmc = 2196360 | doi = 10.1084/jem.185.12.2171 }}
  • {{cite journal | vauthors = Alkhatib G, Berger EA, Murphy PM, Pease JE | title = Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions | journal = J. Biol. Chem. | volume = 272 | issue = 33 | pages = 20420–6 | year = 1997 | pmid = 9252350 | doi = 10.1074/jbc.272.33.20420 }}
  • {{cite journal | vauthors = Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hébert CA | title = Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5 | journal = Biochemistry | volume = 36 | issue = 32 | pages = 9642–8 | year = 1997 | pmid = 9289016 | doi = 10.1021/bi970593z }}
  • {{cite journal | vauthors = Sallusto F, Mackay CR, Lanzavecchia A | title = Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells | journal = Science | volume = 277 | issue = 5334 | pages = 2005–7 | year = 1997 | pmid = 9302298 | doi = 10.1126/science.277.5334.2005 }}
{{refend}}

External links

  • {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2224 | title = Chemokine Receptors: CCR3 | accessdate = | author = | authorlink = | coauthors = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
  • {{MeshName|CCR3+protein,+human}}
  • {{UCSC gene info|CCR3}}
{{NLM content}}{{Cytokine receptors}}{{Clusters of differentiation}}{{Chemokine receptor modulators}}{{DEFAULTSORT:Ccr3 (Gene)}}{{transmembranereceptor-stub}}

2 : Chemokine receptors|Clusters of differentiation
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