| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Endosialin is a protein that in humans is encoded by the CD248 gene.[1][2][3]Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise two other members, CD93 and Thrombomodulin which are better characterized. The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.[4] See also- Cluster of differentiation
References1. ^{{cite journal | vauthors = St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW | title = Genes expressed in human tumor endothelium | journal = Science | volume = 289 | issue = 5482 | pages = 1197–202 |date=Aug 2000 | pmid = 10947988 | pmc = | doi =10.1126/science.289.5482.1197 }}
2. ^{{cite journal | vauthors = Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC | title = Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium | journal = J Biol Chem | volume = 276 | issue = 10 | pages = 7408–14 |date=May 2001 | pmid = 11084048 | pmc = | doi = 10.1074/jbc.M009604200 }}
3. ^{{cite web | title = Entrez Gene: CD248 CD248 molecule, endosialin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57124| accessdate = }}
4. ^{{cite journal | vauthors=Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P|title=Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. |journal=Cancer Immun | volume=6 | issue=|pages=10 |year=2006 |pmid=16875435|doi=}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Rettig WJ, Garin-Chesa P, Healey JH |title=Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 22 |pages= 10832–6 |year= 1992 |pmid= 1438285 |doi=10.1073/pnas.89.22.10832 | pmc=50436 |display-authors=etal}}
- {{cite journal | vauthors=Opavsky R, Haviernik P, Jurkovicova D |title=Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38795–807 |year= 2001 |pmid= 11489895 |doi= 10.1074/jbc.M105241200 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Brady J, Neal J, Sadakar N, Gasque P |title=Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors. |journal=J. Neuropathol. Exp. Neurol. |volume=63 |issue= 12 |pages= 1274–83 |year= 2005 |pmid= 15624764 |doi= }}
- {{cite journal | vauthors=MacFadyen JR, Haworth O, Roberston D |title=Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. |journal=FEBS Lett. |volume=579 |issue= 12 |pages= 2569–75 |year= 2005 |pmid= 15862292 |doi= 10.1016/j.febslet.2005.03.071 |display-authors=etal}}
- {{cite journal | vauthors=Dolznig H, Schweifer N, Puri C |title=Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. |journal=Cancer Immun. |volume=5 |issue= |pages= 10 |year= 2006 |pmid= 16076089 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Tomkowicz B, Rybinski K, Foley B |title=Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 46 |pages= 17965–70 |year= 2008 |pmid= 17986615 |doi= 10.1073/pnas.0705647104 | pmc=2084280 |display-authors=etal}}
{{refend}}External links- {{MeshName|CD248+protein,+human}}
- {{UCSC gene info|CD248}}
{{Clusters of differentiation}}{{DEFAULTSORT:Cd248}}{{membrane-protein-stub}} 1 : Clusters of differentiation |