| 释义 |
- Interactions
- See also
- References
- External links
- Further reading
{{Infobox_gene}}T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.[1]InteractionsCD3D has been shown to interact with CD8A.[2] See also- CD3 (immunology)
- Cluster of differentiation
References1. ^{{cite web | title = Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=915| accessdate = }}
2. ^{{cite journal |last=Doucey |first=Marie-Agnès |author2=Goffin Laurence |author3=Naeher Dieter |author4=Michielin Olivier |author5=Baumgärtner Petra |author6=Guillaume Philippe |author7=Palmer Ed |author8=Luescher Immanuel F |date=Jan 2003 |title=CD3 delta establishes a functional link between the T cell receptor and CD8 |journal=J. Biol. Chem. |volume=278 |issue=5 |pages=3257–64 |publisher= |location = United States| issn = 0021-9258| pmid = 12215456 |doi = 10.1074/jbc.M208119200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Balk SP, Polischuk JE, Probert C |title=Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. |journal=Int. Immunol. |volume=7 |issue= 8 |pages= 1237–41 |year= 1996 |pmid= 7495730 |doi=10.1093/intimm/7.8.1237 |display-authors=etal}}
- {{cite journal | author=Li CJ |title=Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference. |journal=J. Cell. Physiol. |volume=209 |issue= 3 |pages= 695–700 |year= 2007 |pmid= 17001685 |doi= 10.1002/jcp.20817 }}
- {{cite journal | vauthors=Phillips JH, Hori T, Nagler A |title=Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins. |journal=J. Exp. Med. |volume=175 |issue= 4 |pages= 1055–66 |year= 1992 |pmid= 1372642 |doi=10.1084/jem.175.4.1055 | pmc=2119193 |display-authors=etal}}
- {{cite journal | vauthors=Luzzati AL, Giacomini E, Giordani L |title=The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. |journal=Immunol. Lett. |volume=33 |issue= 3 |pages= 307–14 |year= 1992 |pmid= 1385321 |doi=10.1016/0165-2478(92)90078-3 |display-authors=etal}}
- {{cite journal | vauthors=Alarcón B, Ley SC, Sánchez-Madrid F |title=The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. |journal=EMBO J. |volume=10 |issue= 4 |pages= 903–12 |year= 1991 |pmid= 1826255 |doi= | pmc=452733 |display-authors=etal}}
- {{cite journal | vauthors=Hori T, de Waal Malefyt R, Duncan BW |title=Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3. |journal=Int. Immunol. |volume=3 |issue= 4 |pages= 353–7 |year= 1991 |pmid= 1831653 |doi=10.1093/intimm/3.4.353 |display-authors=etal}}
- {{cite journal | vauthors=Ruegg CL, Strand M |title=A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. |journal=Cell. Immunol. |volume=137 |issue= 1 |pages= 1–13 |year= 1991 |pmid= 1832084 |doi=10.1016/0008-8749(91)90051-C }}
- {{cite journal | vauthors=Cefai D, Debre P, Kaczorek M |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=10.1172/JCI114950 | pmc=329852 |display-authors=etal}}
- {{cite journal | vauthors=Luzzati AL, Pugliese O, Giacomini E |title=Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV. |journal=Folia Biol. (Praha) |volume=36 |issue= 1 |pages= 71–7 |year= 1990 |pmid= 2111780 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex. |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 }}
- {{cite journal | vauthors=Alexander D, Goris J, Marais R |title=Dephosphorylation of the human T lymphocyte CD3 antigen. |journal=Eur. J. Biochem. |volume=181 |issue= 1 |pages= 55–65 |year= 1989 |pmid= 2540970 |doi=10.1111/j.1432-1033.1989.tb14693.x |display-authors=etal}}
- {{cite journal | vauthors=Tunnacliffe A, Buluwela L, Rabbitts TH |title=Physical linkage of three CD3 genes on human chromosome 11. |journal=EMBO J. |volume=6 |issue= 10 |pages= 2953–7 |year= 1988 |pmid= 2826124 |doi= | pmc=553731 }}
- {{cite journal | vauthors=van den Elsen P, Shepley BA, Cho M, Terhorst C |title=Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. |journal=Nature |volume=314 |issue= 6011 |pages= 542–4 |year= 1985 |pmid= 2859526 |doi=10.1038/314542a0 |bibcode=1985Natur.314..542V }}
- {{cite journal | vauthors=van den Elsen P, Georgopoulos K, Shepley BA |title=Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 9 |pages= 2944–8 |year= 1986 |pmid= 2939461 |doi=10.1073/pnas.83.9.2944 | pmc=323423 |display-authors=etal}}
- {{cite journal | vauthors=Gold DP, Clevers H, Alarcon B |title=Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 21 |pages= 7649–53 |year= 1987 |pmid= 3478717 |doi=10.1073/pnas.84.21.7649 | pmc=299357 |display-authors=etal|bibcode=1987PNAS...84.7649G}}
- {{cite journal | vauthors=Tunnacliffe A, Sims JE, Rabbitts TH |title=T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. |journal=EMBO J. |volume=5 |issue= 6 |pages= 1245–52 |year= 1986 |pmid= 3488209 |doi= | pmc=1166934 }}
- {{cite journal | vauthors=van den Elsen P, Shepley BA, Borst J |title=Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. |journal=Nature |volume=312 |issue= 5993 |pages= 413–8 |year= 1985 |pmid= 6095101 |doi=10.1038/312413a0 |display-authors=etal|bibcode=1984Natur.312..413V }}
- {{cite journal | vauthors=Oravecz T, Norcross MA |title=Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120. |journal=AIDS Res. Hum. Retroviruses |volume=9 |issue= 10 |pages= 945–55 |year= 1994 |pmid= 7506554 |doi=10.1089/aid.1993.9.945 }}
- {{cite journal | vauthors=Luzzati AL, Giacomini E, Giordani L |title=An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. |journal=Cell. Immunol. |volume=156 |issue= 2 |pages= 286–95 |year= 1994 |pmid= 7517794 |doi= 10.1006/cimm.1994.1175 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=915}}{{NLM content}}{{Clusters of differentiation}}{{membrane-protein-stub}} 1 : Clusters of differentiation |