“CDH3 (gene)”的意思、由来-开放百科全书

Function

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.

Clinical significance

Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.^[2]

Interactions

Further reading

{{cite journal | vauthors = Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R | title = The uvomorulin-anchorage protein alpha catenin is a vinculin homologue | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 20 | pages = 9156–60 | date = Oct 1991 | pmid = 1924379 | pmc = 52671 | doi = 10.1073/pnas.88.20.9156 }}

{{cite journal | vauthors = Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O | title = Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas | journal = Cancer Research | volume = 49 | issue = 8 | pages = 2128–33 | date = Apr 1989 | pmid = 2702654 | doi = }}

{{cite journal | vauthors = Shimoyama Y, Yoshida T, Terada M, Shimosato Y, Abe O, Hirohashi S | title = Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues | journal = The Journal of Cell Biology | volume = 109 | issue = 4 Pt 1 | pages = 1787–94 | date = Oct 1989 | pmid = 2793940 | pmc = 2115800 | doi = 10.1083/jcb.109.4.1787 }}

{{cite journal | vauthors = Palacios J, Benito N, Pizarro A, Suárez A, Espada J, Cano A, Gamallo C | title = Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features | journal = The American Journal of Pathology | volume = 146 | issue = 3 | pages = 605–12 | date = Mar 1995 | pmid = 7534041 | pmc = 1869170 | doi = }}

{{cite journal | vauthors = van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL | title = Expression of cadherins and integrins in human endometrium throughout the menstrual cycle | journal = Fertility and Sterility | volume = 63 | issue = 6 | pages = 1210–6 | date = Jun 1995 | pmid = 7538474 | doi = 10.1016/s0015-0282(16)57599-2}}

{{cite journal | vauthors = Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA | title = E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro | journal = Journal of Cell Science | volume = 107 | issue = 4 | pages = 983–92 | date = Apr 1994 | pmid = 8056851 | doi = }}

{{cite journal | vauthors = Tassin MT, Beziau A, Gubler MC, Boyer B | title = Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes | journal = The International Journal of Developmental Biology | volume = 38 | issue = 1 | pages = 45–54 | date = Mar 1994 | pmid = 8074995 | doi = }}

{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}

{{cite journal | vauthors = Navarro P, Lozano E, Cano A | title = Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin | journal = Journal of Cell Science | volume = 105 | issue = 4 | pages = 923–34 | date = Aug 1993 | pmid = 8227214 | doi = }}

{{cite journal | vauthors = Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z | title = The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts | journal = Experimental Cell Research | volume = 225 | issue = 2 | pages = 328–37 | date = Jun 1996 | pmid = 8660921 | doi = 10.1006/excr.1996.0183 }}

{{cite journal | vauthors = Soler AP, Harner GD, Knudsen KA, McBrearty FX, Grujic E, Salazar H, Han AC, Keshgegian AA | title = Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology | journal = The American Journal of Pathology | volume = 151 | issue = 2 | pages = 471–8 | date = Aug 1997 | pmid = 9250159 | pmc = 1858007 | doi = }}

{{cite journal | vauthors = Wakita H, Furukawa F, Baba S, Takigawa M | title = Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation | journal = International Journal of Cancer | volume = 73 | issue = 3 | pages = 432–9 | date = Nov 1997 | pmid = 9359492 | doi = 10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E }}

{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}

{{cite journal | vauthors = Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF | title = Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity | journal = Genomics | volume = 49 | issue = 3 | pages = 467–71 | date = May 1998 | pmid = 9615235 | doi = 10.1006/geno.1998.5281 }}

{{cite journal | vauthors = Jarrard DF, Paul R, van Bokhoven A, Nguyen SH, Bova GS, Wheelock MJ, Johnson KR, Schalken J, Bussemakers M, Isaacs WB | title = P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer | journal = Clinical Cancer Research | volume = 3 | issue = 11 | pages = 2121–8 | date = Nov 1997 | pmid = 9815605 | doi = }}

{{cite journal | vauthors = Schmeiser K, Grand RJ | title = The fate of E- and P-cadherin during the early stages of apoptosis | journal = Cell Death and Differentiation | volume = 6 | issue = 4 | pages = 377–86 | date = Apr 1999 | pmid = 10381631 | doi = 10.1038/sj.cdd.4400504 }}

{{cite journal | vauthors = Rufas O, Fisch B, Ziv S, Shalgi R | title = Expression of cadherin adhesion molecules on human gametes | journal = Molecular Human Reproduction | volume = 6 | issue = 2 | pages = 163–9 | date = Feb 2000 | pmid = 10655458 | doi = 10.1093/molehr/6.2.163 }}

{{cite journal | vauthors = Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S | title = Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions | journal = Journal of Cell Science | volume = 113 | issue = 16 | pages = 2829–36 | date = Aug 2000 | pmid = 10910767 | doi = }}

{{cite journal | vauthors = Han AC, Edelson MI, Peralta Soler A, Knudsen KA, Lifschitz-Mercer B, Czernobilsky B, Rosenblum NG, Salazar H | title = Cadherin expression in glandular tumors of the cervix | journal = Cancer | volume = 89 | issue = 10 | pages = 2053–8 | date = Nov 2000 | pmid = 11066045 | doi = 10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C }}

{{cite journal | vauthors = Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R | title = Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines | journal = Carcinogenesis | volume = 34 | issue = 11 | pages = 2622–8 | date = Nov 2013 | pmid = 23740836 | doi = 10.1093/carcin/bgt211 }}

Function

Clinical significance

Interactions

See also

References

Further reading

External links