“CEACAM1”的意思、由来-开放百科全书

Function

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.^[1]

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.^[2]

References

1. ^¹{{cite web | title = Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=634| accessdate = }}
2. ^{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = December 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}
3. ^{{cite journal | vauthors = Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N | title = The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 1 | pages = 335–44 | date = January 1999 | pmid = 9867848 | doi = 10.1074/jbc.274.1.335 }}
4. ^{{cite journal | vauthors = Kirshner J, Schumann D, Shively JE | title = CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50338–45 | date = December 2003 | pmid = 14522961 | doi = 10.1074/jbc.M309115200 }}

Further reading

{{cite journal | vauthors = Gray-Owen SD, Blumberg RS | title = CEACAM1: contact-dependent control of immunity | journal = Nature Reviews. Immunology | volume = 6 | issue = 6 | pages = 433–46 | date = June 2006 | pmid = 16724098 | doi = 10.1038/nri1864 }}

{{cite journal | vauthors = Svenberg T, Hammarström S, Zeromski J | title = Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues | journal = Clinical and Experimental Immunology | volume = 36 | issue = 3 | pages = 436–41 | date = June 1979 | pmid = 385181 | pmc = 1537745 | doi = }}

{{cite journal | vauthors = Thompson J, Zimmermann W, Osthus-Bugat P, Schleussner C, Eades-Perner AM, Barnert S, Von Kleist S, Willcocks T, Craig I, Tynan K | title = Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster | journal = Genomics | volume = 12 | issue = 4 | pages = 761–72 | date = April 1992 | pmid = 1572649 | doi = 10.1016/0888-7543(92)90307-E }}

{{cite journal | vauthors = Kuroki M, Arakawa F, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y | title = Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library | journal = Biochemical and Biophysical Research Communications | volume = 176 | issue = 2 | pages = 578–85 | date = April 1991 | pmid = 2025273 | doi = 10.1016/S0006-291X(05)80223-2 }}

{{cite journal | vauthors = Hinoda Y, Neumaier M, Hefta SA, Drzeniek Z, Wagener C, Shively L, Hefta LJ, Shively JE, Paxton RJ | title = Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 18 | pages = 6959–63 | date = September 1988 | pmid = 2457922 | pmc = 282098 | doi = 10.1073/pnas.85.18.6959 }}

{{cite journal | vauthors = Barnett TR, Kretschmer A, Austen DA, Goebel SJ, Hart JT, Elting JJ, Kamarck ME | title = Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family | journal = The Journal of Cell Biology | volume = 108 | issue = 2 | pages = 267–76 | date = February 1989 | pmid = 2537311 | pmc = 2115422 | doi = 10.1083/jcb.108.2.267 }}

{{cite journal | vauthors = Neumaier M, Paululat S, Chan A, Matthaes P, Wagener C | title = Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 22 | pages = 10744–8 | date = November 1993 | pmid = 7504281 | pmc = 47854 | doi = 10.1073/pnas.90.22.10744 }}

{{cite journal | vauthors = Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P | title = Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 41 | pages = 24073–7 | date = October 1995 | pmid = 7592607 | doi = 10.1074/jbc.270.26.15844 }}

{{cite journal | vauthors = Frängsmyr L, Baranov V, Prall F, Yeung MM, Wagener C, Hammarström S | title = Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa | journal = Cancer Research | volume = 55 | issue = 14 | pages = 2963–7 | date = July 1995 | pmid = 7606710 | doi = }}

{{cite journal | vauthors = Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI | title = Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase | journal = Biochemistry | volume = 34 | issue = 29 | pages = 9341–9 | date = July 1995 | pmid = 7626603 | doi = 10.1021/bi00029a009 }}

{{cite journal | vauthors = Nédellec P, Turbide C, Beauchemin N | title = Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene | journal = European Journal of Biochemistry / FEBS | volume = 231 | issue = 1 | pages = 104–14 | date = July 1995 | pmid = 7628460 | doi = 10.1111/j.1432-1033.1995.tb20676.x }}

{{cite journal | vauthors = Watt SM, Fawcett J, Murdoch SJ, Teixeira AM, Gschmeissner SE, Hajibagheri NM, Simmons DL | title = CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant | journal = Blood | volume = 84 | issue = 1 | pages = 200–10 | date = July 1994 | pmid = 8018919 | doi = }}

{{cite journal | vauthors = Hauck W, Nédellec P, Turbide C, Stanners CP, Barnett TR, Beauchemin N | title = Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas | journal = European Journal of Biochemistry / FEBS | volume = 223 | issue = 2 | pages = 529–41 | date = July 1994 | pmid = 8055923 | doi = 10.1111/j.1432-1033.1994.tb19022.x }}

{{cite journal | vauthors = Barnett TR, Drake L, Pickle W | title = Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins | journal = Molecular and Cellular Biology | volume = 13 | issue = 2 | pages = 1273–82 | date = February 1993 | pmid = 8423792 | pmc = 359012 | doi = 10.1128/mcb.13.2.1273}}

{{cite journal | vauthors = Kuroki M, Yamanaka T, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y | title = Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils | journal = Immunological Investigations | volume = 24 | issue = 5 | pages = 829–43 | date = August 1995 | pmid = 8543346 | doi = 10.3109/08820139509060710 }}

{{cite journal | vauthors = Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N | title = The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 1 | pages = 335–44 | date = January 1999 | pmid = 9867848 | doi = 10.1074/jbc.274.1.335 }}

{{cite journal | vauthors = Feuk-Lagerstedt E, Jordan ET, Leffler H, Dahlgren C, Karlsson A | title = Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils | journal = Journal of Immunology | volume = 163 | issue = 10 | pages = 5592–8 | date = November 1999 | pmid = 10553088 | doi = }}

{{cite journal | vauthors = Soni P, Lakkis M, Poy MN, Fernström MA, Najjar SM | title = The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor | journal = Molecular and Cellular Biology | volume = 20 | issue = 11 | pages = 3896–905 | date = June 2000 | pmid = 10805733 | pmc = 85733 | doi = 10.1128/MCB.20.11.3896-3905.2000 }}

{{cite journal | vauthors = Ergün S, Kilik N, Ziegeler G, Hansen A, Nollau P, Götze J, Wurmbach JH, Horst A, Weil J, Fernando M, Wagener C | title = CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor | journal = Molecular Cell | volume = 5 | issue = 2 | pages = 311–20 | date = February 2000 | pmid = 10882072 | doi = 10.1016/S1097-2765(00)80426-8 }}

{{cite journal | vauthors = Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L | title = C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers | journal = Clinical Cancer Research | volume = 6 | issue = 8 | pages = 2988–93 | date = August 2000 | pmid = 10955775 | doi = }}

Function

Interactions

See also

References

Further reading

External links