| 释义 |
- See also
- References
- Further reading
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{{Infobox_gene}}CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene.[1][2]The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements.[2] See also- Ccaat-enhancer-binding proteins
References1. ^{{cite journal | vauthors = Williams SC, Cantwell CA, Johnson PF | title = A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro | journal = Genes Dev | volume = 5 | issue = 9 | pages = 1553–67 |date=Oct 1991 | pmid = 1884998 | pmc = | doi =10.1101/gad.5.9.1553 }}
2. ^1 {{cite web | title = Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1054| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Nishizawa M, Nagata S |title=cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. |journal=FEBS Lett. |volume=299 |issue= 1 |pages= 36–8 |year= 1992 |pmid= 1371974 |doi=10.1016/0014-5793(92)80094-W }}
- {{cite journal | vauthors=Thomassin H, Hamel D, Bernier D |title=Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma. |journal=Nucleic Acids Res. |volume=20 |issue= 12 |pages= 3091–8 |year= 1992 |pmid= 1377818 |doi=10.1093/nar/20.12.3091 | pmc=312443 |display-authors=etal}}
- {{cite journal | vauthors=Nishizawa M, Wakabayashi-Ito N, Nagata S |title=Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1. |journal=FEBS Lett. |volume=282 |issue= 1 |pages= 95–7 |year= 1991 |pmid= 1709121 |doi=10.1016/0014-5793(91)80452-9 }}
- {{cite journal | vauthors=Cooper C, Henderson A, Artandi S |title=Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. |journal=Nucleic Acids Res. |volume=23 |issue= 21 |pages= 4371–7 |year= 1996 |pmid= 7501458 |doi=10.1093/nar/23.21.4371 | pmc=307392 |display-authors=etal}}
- {{cite journal | vauthors=Davydov IV, Bohmann D, Krammer PH, Li-Weber M |title=Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. |journal=Gene |volume=161 |issue= 2 |pages= 271–5 |year= 1995 |pmid= 7665092 |doi=10.1016/0378-1119(95)00271-7 }}
- {{cite journal | vauthors=Lundgren M, Larsson C, Femino A |title=Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. |journal=J. Immunol. |volume=153 |issue= 7 |pages= 2983–95 |year= 1994 |pmid= 8089482 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Martin ML, Lieberman PM, Curran T |title=Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2110–8 |year= 1996 |pmid= 8628277 |doi= | pmc=231198 }}
- {{cite journal | vauthors=Gao H, Parkin S, Johnson PF, Schwartz RC |title=C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38827–37 |year= 2002 |pmid= 12177065 |doi= 10.1074/jbc.M206224200 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Hattori T, Ohoka N, Inoue Y |title=C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer. |journal=Oncogene |volume=22 |issue= 9 |pages= 1273–80 |year= 2003 |pmid= 12618752 |doi= 10.1038/sj.onc.1206204 |display-authors=etal}}
- {{cite journal | vauthors=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097–101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648 }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
- {{cite journal | vauthors=Mullins DN, Crawford EL, Khuder SA |title=CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. |journal=BMC Cancer |volume=5|pages= 141 |year= 2006 |pmid= 16255782 |doi= 10.1186/1471-2407-5-141 | pmc=1310620 |display-authors=etal}}
{{refend}} External links - {{MeshName|CEBPG+protein,+human}}
- {{UCSC gene info|CEBPG}}
{{NLM content}}{{Transcription factors|g1}}{{gene-19-stub}} 1 : Transcription factors |