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词条 Centaurin, alpha 1
释义

  1. Interactions

  2. Model organisms

  3. References

  4. Further reading

{{Infobox_gene}}Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.[1][2]

Interactions

Centaurin, alpha 1 has been shown to interact with:

{{div col|colwidth=20em}}
  • Casein kinase 1, alpha 1[3][4]
  • Nucleolin,[5]
  • P110α,[6]
  • PRKCI,[6]
  • Protein kinase D1,[6] and
  • Protein kinase Mζ.[6]
{{Div col end}}

Model organisms

Model organisms have been used in the study of ADAP1 function. A conditional knockout mouse line called Adap1tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed:

  • In-depth immunological phenotyping[13]
  • in-depth bone and cartilage phenotyping[14]

References

1. ^{{cite journal | vauthors = Venkateswarlu K, Oatey PB, Tavaré JM, Jackson TR, Cullen PJ | title = Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1 | journal = The Biochemical Journal | volume = 340 | issue = 2 | pages = 359–63 | date = Jun 1999 | pmid = 10333475 | pmc = 1220257 | doi = 10.1042/0264-6021:3400359 }}
2. ^{{cite web | title = Entrez Gene: CENTA1 centaurin, alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11033| accessdate = }}
3. ^{{cite journal | vauthors = Dubois T, Howell S, Zemlickova E, Aitken A | title = Identification of casein kinase Ialpha interacting protein partners | journal = FEBS Letters | volume = 517 | issue = 1-3 | pages = 167–71 | date = Apr 2002 | pmid = 12062430 | doi = 10.1016/s0014-5793(02)02614-5}}
4. ^{{cite journal | vauthors = Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A | title = Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18757–64 | date = Jun 2001 | pmid = 11278595 | doi = 10.1074/jbc.M010005200 }}
5. ^{{cite journal | vauthors = Dubois T, Zemlickova E, Howell S, Aitken A | title = Centaurin-alpha 1 associates in vitro and in vivo with nucleolin | journal = Biochemical and Biophysical Research Communications | volume = 301 | issue = 2 | pages = 502–8 | date = Feb 2003 | pmid = 12565890 | doi = 10.1016/s0006-291x(02)03010-3}}
6. ^1 2 3 {{cite journal | vauthors = Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A | title = Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C | journal = Biochemical and Biophysical Research Communications | volume = 307 | issue = 3 | pages = 459–65 | date = Aug 2003 | pmid = 12893243 | doi = 10.1016/s0006-291x(03)01187-2}}
7. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
8. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Adap1#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
9. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
10. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
11. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
12. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}
13. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Adap1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}
14. ^1 {{cite web |url=http://www.boneandcartilage.com/ |title=OBCD Consortium}}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = Venkateswarlu K, Cullen PJ | title = Molecular cloning and functional characterization of a human homologue of centaurin-alpha | journal = Biochemical and Biophysical Research Communications | volume = 262 | issue = 1 | pages = 237–44 | date = Aug 1999 | pmid = 10448098 | doi = 10.1006/bbrc.1999.1065 }}
  • {{cite journal | vauthors = Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A | title = Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18757–64 | date = Jun 2001 | pmid = 11278595 | doi = 10.1074/jbc.M010005200 }}
  • {{cite journal | vauthors = Sedehizade F, Hanck T, Stricker R, Horstmayer A, Bernstein HG, Reiser G | title = Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells | journal = Brain Research. Molecular Brain Research | volume = 99 | issue = 1 | pages = 1–11 | date = Feb 2002 | pmid = 11869802 | doi = 10.1016/S0169-328X(01)00335-7 }}
  • {{cite journal | vauthors = Whitley P, Gibbard AM, Koumanov F, Oldfield S, Kilgour EE, Prestwich GD, Holman GD | title = Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle | journal = European Journal of Cell Biology | volume = 81 | issue = 4 | pages = 222–30 | date = Apr 2002 | pmid = 12018390 | doi = 10.1078/0171-9335-00242 }}
  • {{cite journal | vauthors = Reiser G, Bernstein HG | title = Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha | journal = NeuroReport | volume = 13 | issue = 18 | pages = 2417–9 | date = Dec 2002 | pmid = 12499840 | doi = 10.1097/01.wnr.0000048005.96487.10 }}
  • {{cite journal | vauthors = Dubois T, Zemlickova E, Howell S, Aitken A | title = Centaurin-alpha 1 associates in vitro and in vivo with nucleolin | journal = Biochemical and Biophysical Research Communications | volume = 301 | issue = 2 | pages = 502–8 | date = Feb 2003 | pmid = 12565890 | doi = 10.1016/S0006-291X(02)03010-3 }}
  • {{cite journal | vauthors = Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 | date = May 2003 | pmid = 12761501 | doi = 10.1038/sj.onc.1206406 }}
  • {{cite journal | vauthors = Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A | title = Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C | journal = Biochemical and Biophysical Research Communications | volume = 307 | issue = 3 | pages = 459–65 | date = Aug 2003 | pmid = 12893243 | doi = 10.1016/S0006-291X(03)01187-2 }}
  • {{cite journal | vauthors = Venkateswarlu K, Brandom KG, Lawrence JL | title = Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization | journal = The Journal of Biological Chemistry | volume = 279 | issue = 8 | pages = 6205–8 | date = Feb 2004 | pmid = 14625293 | doi = 10.1074/jbc.C300482200 | url = http://www.jbc.org/content/279/8/6205.full.pdf }}
  • {{cite journal | vauthors = Hanck T, Stricker R, Sedehizade F, Reiser G | title = Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins | journal = Journal of Neurochemistry | volume = 88 | issue = 2 | pages = 326–36 | date = Jan 2004 | pmid = 14690521 | doi = 10.1046/j.1471-4159.2003.02143.x }}
  • {{cite journal | vauthors = Reiser G, Bernstein HG | title = Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin | journal = NeuroReport | volume = 15 | issue = 1 | pages = 147–8 | date = Jan 2004 | pmid = 15106847 | doi = 10.1097/00001756-200401190-00028 }}
  • {{cite journal | vauthors = Thacker E, Kearns B, Chapman C, Hammond J, Howell A, Theibert A | title = The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton | journal = European Journal of Cell Biology | volume = 83 | issue = 10 | pages = 541–54 | date = Oct 2004 | pmid = 15679100 | doi = 10.1078/0171-9335-00416 }}
  • {{cite journal | vauthors = Lawrence J, Mundell SJ, Yun H, Kelly E, Venkateswarlu K | title = Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization | journal = Molecular Pharmacology | volume = 67 | issue = 6 | pages = 1822–8 | date = Jun 2005 | pmid = 15778454 | doi = 10.1124/mol.105.011338 }}
  • {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
  • {{cite journal | vauthors = Hayashi H, Matsuzaki O, Muramatsu S, Tsuchiya Y, Harada T, Suzuki Y, Sugano S, Matsuda A, Nishida E | title = Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 281 | issue = 3 | pages = 1332–7 | date = Jan 2006 | pmid = 16287813 | doi = 10.1074/jbc.M505905200 }}
  • {{cite journal | vauthors = Sedehizade F, von Klot C, Hanck T, Reiser G | title = p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor | journal = Neurochemical Research | volume = 30 | issue = 10 | pages = 1319–30 | date = Oct 2005 | pmid = 16341594 | doi = 10.1007/s11064-005-8804-1 }}
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