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词条 CENTG1
释义

  1. Interactions

  2. References

  3. External links

  4. Further reading

{{Infobox_gene}}Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.[1]

Interactions

CENTG1 has been shown to interact with:

  • EPB41L1,[2]
  • HOMER1[2] and
  • PIK3R1.[3]

References

1. ^{{cite web | title = Entrez Gene: CENTG1 centaurin, gamma 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116986| accessdate = }}
2. ^{{cite journal | vauthors = Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K | title = PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis | journal = Nat. Neurosci. | volume = 6 | issue = 11 | pages = 1153–61 | date = November 2003 | pmid = 14528310 | doi = 10.1038/nn1134 }}
3. ^1 {{cite journal | vauthors = Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH | title = Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N | journal = Cell | volume = 103 | issue = 6 | pages = 919–30 | date = December 2000 | pmid = 11136977 | doi = 10.1016/S0092-8674(00)00195-1}}

External links

  • {{UCSC gene info|AGAP2}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. | journal = DNA Res. | volume = 3 | issue = 1 | pages = 17–24 | year = 1996 | pmid = 8724849 | doi = 10.1093/dnares/3.1.17 }}
  • {{cite journal | vauthors = Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS | title = Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. | journal = Genomics | volume = 42 | issue = 2 | pages = 295–301 | year = 1997 | pmid = 9192850 | doi = 10.1006/geno.1997.4727 }}
  • {{cite journal | vauthors = Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH | title = Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. | journal = Cell | volume = 103 | issue = 6 | pages = 919–30 | year = 2001 | pmid = 11136977 | doi = 10.1016/S0092-8674(00)00195-1 }}
  • {{cite journal | vauthors = Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH | title = Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. | journal = Nature | volume = 415 | issue = 6871 | pages = 541–4 | year = 2002 | pmid = 11823862 | doi = 10.1038/415541a }}
  • {{cite journal | vauthors = Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA | title = AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. | journal = J. Biol. Chem. | volume = 277 | issue = 50 | pages = 48965–75 | year = 2003 | pmid = 12388557 | doi = 10.1074/jbc.M202969200 }}
  • {{cite journal | vauthors = Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M | title = GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. | journal = Mol. Cell. Biol. | volume = 23 | issue = 7 | pages = 2476–88 | year = 2003 | pmid = 12640130 | pmc = 150724 | doi = 10.1128/MCB.23.7.2476-2488.2003 }}
  • {{cite journal | vauthors = Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K | title = PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. | journal = Nat. Neurosci. | volume = 6 | issue = 11 | pages = 1153–61 | year = 2003 | pmid = 14528310 | doi = 10.1038/nn1134 }}
  • {{cite journal | vauthors = Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K | title = PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. | journal = J. Biol. Chem. | volume = 279 | issue = 16 | pages = 16441–51 | year = 2004 | pmid = 14761976 | doi = 10.1074/jbc.M312175200 }}
  • {{cite journal | vauthors = Ahn JY, Hu Y, Kroll TG, Allard P, Ye K | title = PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 18 | pages = 6993–8 | year = 2004 | pmid = 15118108 | pmc = 406454 | doi = 10.1073/pnas.0400921101 }}
  • {{cite journal | vauthors = Nie Z, Fei J, Premont RT, Randazzo PA | title = The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. | journal = J. Cell Sci. | volume = 118 | issue = Pt 15 | pages = 3555–66 | year = 2005 | pmid = 16079295 | doi = 10.1242/jcs.02486 }}
  • {{cite journal | vauthors = Knobbe CB, Trampe-Kieslich A, Reifenberger G | title = Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. | journal = Neuropathol. Appl. Neurobiol. | volume = 31 | issue = 5 | pages = 486–90 | year = 2005 | pmid = 16150119 | doi = 10.1111/j.1365-2990.2005.00660.x }}
  • {{cite journal | vauthors = Hu Y, Liu Z, Ye K | title = Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 46 | pages = 16853–8 | year = 2006 | pmid = 16263930 | pmc = 1283830 | doi = 10.1073/pnas.0507365102 }}
  • {{cite journal | vauthors = Tang X, Feng Y, Ye K | title = Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. | journal = Cell Death Differ. | volume = 14 | issue = 2 | pages = 368–77 | year = 2007 | pmid = 16841086 | doi = 10.1038/sj.cdd.4402011 }}
  • {{cite journal | vauthors = Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA | title = The centaurin gamma-1 GTPase-like domain functions as an NTPase. | journal = Biochem. J. | volume = 401 | issue = 3 | pages = 679–88 | year = 2007 | pmid = 17037982 | pmc = 1770848 | doi = 10.1042/BJ20060555 }}
  • {{cite journal | vauthors = Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G | title = M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. | journal = J. Virol. | volume = 81 | issue = 5 | pages = 2340–8 | year = 2007 | pmid = 17151107 | pmc = 1865929 | doi = 10.1128/JVI.01310-06 }}
  • {{cite journal | vauthors = Liu X, Hu Y, Hao C, Rempel SA, Ye K | title = PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion. | journal = Oncogene | volume = 26 | issue = 34 | pages = 4918–27 | year = 2007 | pmid = 17297440 | doi = 10.1038/sj.onc.1210290 }}
  • {{cite journal | vauthors = Dunphy JL, Ye K, Casanova JE | title = Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. | journal = Traffic | volume = 8 | issue = 6 | pages = 661–72 | year = 2007 | pmid = 17461797 | doi = 10.1111/j.1600-0854.2007.00561.x }}
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