| 词条 | Centrin |
| 释义 |
| Name = Caltractin | image = SkMLCK.png | width = | caption = Crystal structure of the SdCen/skMLCK complex.[1] | Organism = Scherffelia dubia | TaxID = 3190 | Symbol = caltractin | AltSymbols = | IUPHAR_id = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | CAS_number = | CAS_supplemental = | DrugBank = | EntrezGene = | PDB = | RefSeqmRNA = X69220 | RefSeqProtein = | UniProt = Q06827 | ECnumber = | Chromosome = | EntrezChromosome = | GenLoc_start = | GenLoc_end = }} Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes. Centrins are present in the centrioles and pericentriolar lattice.[2][3] Human centrin genes are CETN1, CETN2 and CETN3. Centrin was first isolated and characterized from the flagellar roots of the green alga Tetraselmis striata.[4] FunctionCentrins are required for duplication of centrioles.[3] They may also play a role in severing of microtubules by causing calcium-mediated contraction.[5] The majority of centrin in the cell is non-centrosomal whose function is not yet clear.[6] StructureCentrin belongs to the EF-hand superfamily of calcium-binding proteins and has four calcium-binding EF-hands.[7] It has a molecular weight of 20 kDa.[8] {{Clear}}See also
References1. ^{{cite web |url=http://www.rcsb.org/pdb/explore/explore.do?structureId=3KF9 |title=RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex |website= |accessdate=}} {{protein-stub}}2. ^{{Cite journal| pmid = 1305481| year = 1992| last1 = Baron | first1 = A. T.| last2 = Greenwood| last3 = Bazinet| last4 = Salisbury| title = Centrin is a component of the pericentriolar lattice| volume = 76| issue = 3| pages = 383–388| journal = Biology of the Cell / Under the Auspices of the European Cell Biology Organization | first2 = T. M. | first3 = C. W. | first4 = J. L.| doi = 10.1016/0248-4900(92)90442-4}} 3. ^1 {{cite journal |vauthors=Salisbury JL, Suino KM, Busby R, Springett M | title = Centrin-2 is required for centriole duplication in mammalian cells | journal = Curr. Biol. | volume = 12 | issue = 15 | pages = 1287–92 | year = 2002 | pmid = 12176356 | doi = 10.1016/S0960-9822(02)01019-9}} 4. ^{{cite journal | vauthors = Salisbury JL, Baron A, Surek B, Melkonian M | author4-link = Michael Melkonian | title = Striated flagellar roots: isolation and partial characterization of a calcium-modulated contractile organelle | journal = J. Cell Biol. | volume = 99 | issue = 3 | pages = 962–70 | year = 1984 | pmid = 6381510 | pmc = 2113404 | doi = 10.1083/jcb.99.3.962}} 5. ^{{Cite journal| last1 = Wolfrum | first1 = U.| title = Centrin in the photoreceptor cells of mammalian retinae| journal = Cell Motility and the Cytoskeleton| volume = 32| issue = 1| pages = 55–64| year = 1995| pmid = 8674134| doi = 10.1002/cm.970320107}} 6. ^{{cite journal |vauthors=Paoletti A, Moudjou M, Paintrand M, Salisbury JL, Bornens M | title = Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles | journal = J. Cell Sci. | volume = 109 | issue = Pt 13 | pages = 3089–102 | year = 1996 | pmid = 9004043 | doi = }} 7. ^{{cite journal | author = Salisbury JL | title = Centrin, centrosomes, and mitotic spindle poles | journal = Curr. Opin. Cell Biol. | volume = 7 | issue = 1 | pages = 39–45 | year = 1995 | pmid = 7755988 | doi = 10.1016/0955-0674(95)80043-3}} 8. ^{{cite journal |vauthors=Levy YY, Lai EY, Remillard SP, Heintzelman MB, Fulton C | title = Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs in Naegleria and other organisms | journal = Cell Motil. Cytoskeleton | volume = 33 | issue = 4 | pages = 298–323 | year = 1996 | pmid = 8801035 | doi = 10.1002/(SICI)1097-0169(1996)33:4<298::AID-CM6>3.0.CO;2-5 }} 1 : Protein families |
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