| 释义 |
- Function
- References
- External links
- Further reading
{{Infobox_gene}}Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.[1][2] Function This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.[1] References 1. ^1 {{cite web | title = Entrez Gene: centrosomal protein 120kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153241| accessdate = }}
2. ^{{cite journal |vauthors=Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH | title = Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool | journal = Neuron | volume = 56 | issue = 1 | pages = 79–93 |date=October 2007 | pmid = 17920017 | pmc = 2642594 | doi = 10.1016/j.neuron.2007.08.026 | url = }}
External links- {{UCSC gene info|CEP120}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Vasan RS, Glazer NL, Felix JF |title=Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data |journal=JAMA |volume=302 |issue= 2 |pages= 168–78 |year= 2009 |pmid= 19584346 |pmc=2975567 |doi= 10.1001/jama.2009.978-a |display-authors=etal}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |pmc=1356129 |doi= 10.1101/gr.4039406 |display-authors=etal}}
- {{cite journal |vauthors=Guerrier S, Polleux F |title=The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration |journal=Neuron |volume=56 |issue= 1 |pages= 1–3 |year= 2007 |pmid= 17920006 |doi= 10.1016/j.neuron.2007.09.019 }}
- {{cite journal |vauthors=Thorleifsson G, Walters GB, Gudbjartsson DF |title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity |journal=Nat. Genet. |volume=41 |issue= 1 |pages= 18–24 |year= 2009 |pmid= 19079260 |doi= 10.1038/ng.274 |display-authors=etal}}
{{refend}}{{Centrosome}}{{gene-5-stub}} 1 : Centrosome |