| 词条 | CGS-12066A |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 451551563 | IUPAC_name = 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline | image = CGS-12066A.svg | width = 240 | tradename = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 109028-10-6 | PubChem = 2689 | IUPHAR_ligand = 109 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 2588 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = LXFHSCDLMBZYKY-UHFFFAOYSA-N | C=17 | H=17 | F=3 | N=4 | molecular_weight = 334.338 g/mol | smiles = C3CN(C)CCN3c2nc1cc(C(F)(F)F)ccc1n4cccc24 }}CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT2 receptor subtypes.[1][2] It is used for studying the role of the 5-HT1B receptor in various processes including perception of pain and the sleep-wake cycle.[3][4] References1. ^Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004 Aug;370(2):114-23. {{DOI|10.1007/s00210-004-0951-4}} {{PMID|15322733}} {{Serotonergics}}{{Piperazines}}{{DEFAULTSORT:Cgs-12066a}}{{nervous-system-drug-stub}}2. ^Jeong HS, Jang MJ, Park JS. Effects of CGS-12066A on medial vestibular nuclear neurons. Brain Research. 15 March 2005;1038(1):118-21. {{PMID|15748881}} 3. ^Monti JM, Jantos H. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Progress in Brain Research. 2008;172:625-46. {{PMID|18772053}} 4. ^Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 20 January 2010;165(2):561-8. {{PMID|19837141}} 4 : Serotonin receptor agonists|Trifluoromethyl compounds|Piperazines|Quinoxalines |
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