| 词条 | CGS-9896 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 455086743 | IUPAC_name = 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one | image = CGS-9896.svg | width = 180 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 77779-36-3 | ATC_prefix = none | ATC_suffix = | PubChem = 108030 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 97139 | C=16 | H=10 | Cl=1 | N=3 | O=1 | molecular_weight = 295.7231 g/mol | smiles = C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = QCBUAKLOWCOUCR-UHFFFAOYSA-N }}CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1] CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5] References1. ^{{cite journal |vauthors=Leidenheimer NJ, Schechter MD |title=Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex |journal=Pharmacol Biochem Behav |volume=31 |issue=2 |pages=249–54 |date=Oct 1988 |pmid=2854261 |url=http://linkinghub.elsevier.com/retrieve/pii/0091-3057(88)90342-5 |doi=10.1016/0091-3057(88)90342-5}} {{Anxiolytics}}{{GABAAR PAMs}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Bernasconi R, Marescaux C, Vergnes M |title=Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models |journal=J Neural Transm |volume=71 |issue=1 |pages=11–27 |year=1988 |pmid=3343593 |doi=10.1007/BF01259406 |display-authors=etal}} 3. ^{{cite journal |vauthors=Rump S, Raszewski W, Gidynska T, Galecka E |title=Effects of CGS 9896 in acute experimental intoxication with fluostigmine |journal=Arch. Toxicol. |volume=64 |issue=5 |pages=412–3 |year=1990 |pmid=2206111 |doi=10.1007/BF01973465 }} 4. ^{{cite journal |vauthors=Chen SW, Davies MF, Loew GH |title=Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake |journal=Pharmacol Biochem Behav |volume=51 |issue=2–3 |pages=499–503 |year=1995 |pmid=7667375 |url=http://linkinghub.elsevier.com/retrieve/pii/0091-3057(95)00020-W |doi=10.1016/0091-3057(95)00020-W}} 5. ^{{cite journal |vauthors=Najim RA, Karim KH |title=Effect of CGS 9896 on stress-induced gastric ulcer in rat |journal=Clin Exp Pharmacol Physiol. |volume=17 |issue=2 |pages=157–161 |date=Feb 1990 |pmid=2109664 |doi=10.1111/j.1440-1681.1990.tb01298.x }} 6 : Anxiolytics|Pyrazoloquinolines|Lactams|Chloroarenes|GABAA receptor positive allosteric modulators|Experimental drugs |
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