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词条 CHAF1A
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

  5. External links

{{Infobox_gene}}Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.[1][2]

Function

Chromatin assembly factor I (CAF-1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone tetramers onto replicating DNA in vitro (Kaufman et al., 1995).[supplied by OMIM][2]

Interactions

CHAF1A has been shown to interact with:

  • ASF1A,[4]
  • ASF1B,[3][4]
  • BLM,[5]
  • CBX5,[8][6] and
  • MBD1.[7]

References

1. ^{{cite journal | vauthors = Kaufman PD, Kobayashi R, Kessler N, Stillman B | title = The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication | journal = Cell | volume = 81 | issue = 7 | pages = 1105–14 | date = August 1995 | pmid = 7600578 | pmc = | doi = 10.1016/S0092-8674(05)80015-7 }}
2. ^1 {{cite web | title = Entrez Gene: CHAF1A chromatin assembly factor 1, subunit A (p150)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10036| accessdate = }}
3. ^1 {{cite journal | vauthors = Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G | title = Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway | journal = EMBO Rep. | volume = 3 | issue = 4 | pages = 329–34 | date = April 2002 | pmid = 11897662 | pmc = 1084056 | doi = 10.1093/embo-reports/kvf068 }}
4. ^{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
5. ^{{cite journal | vauthors = Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I | title = Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1 | journal = Mol. Cell. Biol. | volume = 24 | issue = 11 | pages = 4710–9 | date = June 2004 | pmid = 15143166 | pmc = 416397 | doi = 10.1128/MCB.24.11.4710-4719.2004 }}
6. ^{{cite journal | vauthors = Lechner MS, Begg GE, Speicher DW, Rauscher FJ | title = Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6449–65 | date = September 2000 | pmid = 10938122 | pmc = 86120 | doi = 10.1128/mcb.20.17.6449-6465.2000}}
7. ^1 {{cite journal | vauthors = Reese BE, Bachman KE, Baylin SB, Rountree MR | title = The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1 | journal = Mol. Cell. Biol. | volume = 23 | issue = 9 | pages = 3226–36 | date = May 2003 | pmid = 12697822 | pmc = 153189 | doi = 10.1128/mcb.23.9.3226-3236.2003}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Ridgway P, Almouzni G | title = CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair | journal = J. Cell Sci. | volume = 113 | issue = 15 | pages = 2647–58 | year = 2000 | pmid = 10893180 | doi = }}
  • {{cite journal | vauthors = Verreault A, Kaufman PD, Kobayashi R, Stillman B | title = Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4 | journal = Cell | volume = 87 | issue = 1 | pages = 95–104 | year = 1996 | pmid = 8858152 | doi = 10.1016/S0092-8674(00)81326-4 }}
  • {{cite journal | vauthors = Marheineke K, Krude T | title = Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle | journal = J. Biol. Chem. | volume = 273 | issue = 24 | pages = 15279–86 | year = 1998 | pmid = 9614144 | doi = 10.1074/jbc.273.24.15279 }}
  • {{cite journal | vauthors = Shibahara K, Stillman B | title = Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin | journal = Cell | volume = 96 | issue = 4 | pages = 575–85 | year = 1999 | pmid = 10052459 | doi = 10.1016/S0092-8674(00)80661-3 }}
  • {{cite journal | vauthors = Murzina N, Verreault A, Laue E, Stillman B | title = Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins | journal = Mol. Cell | volume = 4 | issue = 4 | pages = 529–40 | year = 1999 | pmid = 10549285 | doi = 10.1016/S1097-2765(00)80204-X }}
  • {{cite journal | vauthors = Moggs JG, Grandi P, Quivy JP, Jónsson ZO, Hübscher U, Becker PB, Almouzni G | title = A CAF-1–PCNA-Mediated Chromatin Assembly Pathway Triggered by Sensing DNA Damage | journal = Mol. Cell. Biol. | volume = 20 | issue = 4 | pages = 1206–18 | year = 2000 | pmid = 10648606 | pmc = 85246 | doi = 10.1128/MCB.20.4.1206-1218.2000 }}
  • {{cite journal | vauthors = Lechner MS, Begg GE, Speicher DW, Rauscher FJ | title = Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6449–65 | year = 2000 | pmid = 10938122 | pmc = 86120 | doi = 10.1128/MCB.20.17.6449-6465.2000 }}
  • {{cite journal | vauthors = Dong H, Lin W, Zhang CK, Xiong H, Fu G, Jin WR, Chen R, Chen Z, Qi ZT, Huang GM | title = Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene | journal = Gene | volume = 264 | issue = 2 | pages = 187–96 | year = 2001 | pmid = 11250073 | doi = 10.1016/S0378-1119(01)00335-3 }}
  • {{cite journal | vauthors = Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G | title = Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway | journal = EMBO Rep. | volume = 3 | issue = 4 | pages = 329–34 | year = 2002 | pmid = 11897662 | pmc = 1084056 | doi = 10.1093/embo-reports/kvf068 }}
  • {{cite journal | vauthors = Reese BE, Bachman KE, Baylin SB, Rountree MR | title = The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1 | journal = Mol. Cell. Biol. | volume = 23 | issue = 9 | pages = 3226–36 | year = 2003 | pmid = 12697822 | pmc = 153189 | doi = 10.1128/MCB.23.9.3226-3236.2003 }}
  • {{cite journal | vauthors = Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L | title = BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms | journal = J. Cell Sci. | volume = 116 | issue = Pt 14 | pages = 2929–36 | year = 2004 | pmid = 12771185 | doi = 10.1242/jcs.00480 }}
  • {{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | year = 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}
  • {{cite journal | vauthors = Glinsky GV, Glinskii AB, Stephenson AJ, Hoffman RM, Gerald WL | title = Gene expression profiling predicts clinical outcome of prostate cancer | journal = J. Clin. Invest. | volume = 113 | issue = 6 | pages = 913–23 | year = 2004 | pmid = 15067324 | pmc = 362118 | doi = 10.1172/JCI20032 }}
  • {{cite journal | vauthors = Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I | title = Physical and Functional Interaction between the Bloom's Syndrome Gene Product and the Largest Subunit of Chromatin Assembly Factor 1 | journal = Mol. Cell. Biol. | volume = 24 | issue = 11 | pages = 4710–9 | year = 2004 | pmid = 15143166 | pmc = 416397 | doi = 10.1128/MCB.24.11.4710-4719.2004 }}
  • {{cite journal | vauthors = Lehner B, Sanderson CM | title = A Protein Interaction Framework for Human mRNA Degradation | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1315–23 | year = 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
  • {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
  • {{cite journal | vauthors = Sarraf SA, Stancheva I | title = Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly | journal = Mol. Cell | volume = 15 | issue = 4 | pages = 595–605 | year = 2004 | pmid = 15327775 | doi = 10.1016/j.molcel.2004.06.043 }}
{{refend}}

External links

  • {{UCSC genome browser|CHAF1A}}
  • {{UCSC gene details|CHAF1A}}
{{gene-19-stub}}
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