| 释义 |
- Interactions
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{{Infobox_gene}}Chromodomain-helicase-DNA-binding protein 1 is an enzyme that in humans is encoded by the CHD1 gene.[1][2][3]The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.[3] InteractionsCHD1 has been shown to interact with Nuclear receptor co-repressor 1.[4] References1. ^{{cite journal | vauthors = Delmas V, Stokes DG, Perry RP | title = A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 6 | pages = 2414–8 |date=Apr 1993 | pmid = 8460153 | pmc = 46097 | doi =10.1073/pnas.90.6.2414 | bibcode = 1993PNAS...90.2414D }}
2. ^{{cite journal | vauthors = Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS | title = Characterization of the CHD family of proteins | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 21 | pages = 11472–7 |date=Nov 1997 | pmid = 9326634 | pmc = 23509 | doi =10.1073/pnas.94.21.11472 | bibcode = 1997PNAS...9411472W }}
3. ^1 {{cite web | title = Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1105| accessdate = }}
4. ^{{cite journal |last=Tai |first=Helen H |author2=Geisterfer Margit |author3=Bell John C |author4=Moniwa Mariko |author5=Davie James R |author6=Boucher Lorrie |author7=McBurney Michael W |date=Aug 2003 |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue=1 |pages=170–6 |publisher= |location = United States| issn = 0006-291X| pmid = 12890497 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)01354-8 }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Stokes DG, Perry RP |title=DNA-binding and chromatin localization properties of CHD1 |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2745–53 |year= 1995 |pmid= 7739555 |doi= | pmc=230505 }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal | vauthors=Kelley DE, Stokes DG, Perry RP |title=CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin |journal=Chromosoma |volume=108 |issue= 1 |pages= 10–25 |year= 1999 |pmid= 10199952 |doi=10.1007/s004120050347 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal | vauthors=Salomon AR, Ficarro SB, Brill LM |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 | pmc=141014 |display-authors=etal|bibcode=2003PNAS..100..443S }}
- {{cite journal | vauthors=Tai HH, Geisterfer M, Bell JC |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 1 |pages= 170–6 |year= 2003 |pmid= 12890497 |doi=10.1016/S0006-291X(03)01354-8 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}}
- {{cite journal | vauthors=Sims RJ, Chen CF, Santos-Rosa H |title=HUMAN BUT NOT YEAST CHD1 BINDS DIRECTLY AND SELECTIVELY TO HISTONE H3 METHYLATED AT LYSINE 4 VIA ITS TANDEM CHROMODOMAINS |journal=J. Biol. Chem. |volume=280 |issue= 51 |pages= 41789–92 |year= 2006 |pmid= 16263726 |doi= 10.1074/jbc.C500395200 | pmc=1421377 |display-authors=etal}}
- {{cite journal | vauthors=Flanagan JF, Mi LZ, Chruszcz M |title=Double chromodomains cooperate to recognize the methylated histone H3 tail |journal=Nature |volume=438 |issue= 7071 |pages= 1181–5 |year= 2006 |pmid= 16372014 |doi= 10.1038/nature04290 |display-authors=etal|bibcode=2005Natur.438.1181F }}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
- {{cite journal | vauthors=Okuda M, Horikoshi M, Nishimura Y |title=Structural polymorphism of chromodomains in Chd1 |journal=J. Mol. Biol. |volume=365 |issue= 4 |pages= 1047–62 |year= 2007 |pmid= 17098252 |doi= 10.1016/j.jmb.2006.10.039 }}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=1105}}{{gene-5-stub}} |