请输入您要查询的百科知识：

　

词条 CHD4
释义

  1. Function

  2. Interactions

  3. References

  4. External links

  5. Further reading

{{For|the TC LID|Thamesford (Harydale Farms) Aerodrome}}{{Infobox_gene}}Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene.[1][2][3]

Function

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.[3]

Interactions

CHD4 has been shown to interact with HDAC1,[4][5][6] Histone deacetylase 2,[6][7][8] MTA2,[4] SATB1[9] and Ataxia telangiectasia and Rad3 related.[8]

References

1. ^{{cite journal | vauthors = Seelig HP, Moosbrugger I, Ehrfeld H, Fink T, Renz M, Genth E | title = The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation | journal = Arthritis and Rheumatism | volume = 38 | issue = 10 | pages = 1389–99 | date = Oct 1995 | pmid = 7575689 | pmc = | doi = 10.1002/art.1780381006 }}
2. ^{{cite journal | vauthors = Seelig HP, Renz M, Targoff IN, Ge Q, Frank MB | title = Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen | journal = Arthritis and Rheumatism | volume = 39 | issue = 10 | pages = 1769–71 | date = Oct 1996 | pmid = 8843877 | pmc = | doi = 10.1002/art.1780391029 }}
3. ^1 {{cite web | title = Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1108| accessdate = }}
4. ^1 {{cite journal | vauthors = Yao YL, Yang WM | title = The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 42560–8 | date = Oct 2003 | pmid = 12920132 | doi = 10.1074/jbc.M302955200 }}
5. ^{{cite journal | vauthors = Grozinger CM, Hassig CA, Schreiber SL | title = Three proteins define a class of human histone deacetylases related to yeast Hda1p | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 9 | pages = 4868–73 | date = Apr 1999 | pmid = 10220385 | pmc = 21783 | doi = 10.1073/pnas.96.9.4868 }}
6. ^1 {{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | date = Oct 1998 | pmid = 9804427 | doi = 10.1038/27699 }}
7. ^{{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = Feb 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
8. ^1 {{cite journal | vauthors = Schmidt DR, Schreiber SL | title = Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4 | journal = Biochemistry | volume = 38 | issue = 44 | pages = 14711–7 | date = Nov 1999 | pmid = 10545197 | doi = 10.1021/bi991614n | citeseerx = 10.1.1.559.7745 }}
9. ^{{cite journal | vauthors = Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T | title = SATB1 targets chromatin remodelling to regulate genes over long distances | journal = Nature | volume = 419 | issue = 6907 | pages = 641–5 | date = Oct 2002 | pmid = 12374985 | doi = 10.1038/nature01084 | url = https://digital.library.unt.edu/ark:/67531/metadc733622/ }}

External links

  • {{UCSC gene info|CHD4}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Denslow SA, Wade PA | title = The human Mi-2/NuRD complex and gene regulation | journal = Oncogene | volume = 26 | issue = 37 | pages = 5433–8 | date = Aug 2007 | pmid = 17694084 | doi = 10.1038/sj.onc.1210611 }}
  • {{cite journal | vauthors = Ge Q, Nilasena DS, O'Brien CA, Frank MB, Targoff IN | title = Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen | journal = The Journal of Clinical Investigation | volume = 96 | issue = 4 | pages = 1730–7 | date = Oct 1995 | pmid = 7560064 | pmc = 185809 | doi = 10.1172/JCI118218 }}
  • {{cite journal | vauthors = Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS | title = Characterization of the CHD family of proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 21 | pages = 11472–7 | date = Oct 1997 | pmid = 9326634 | pmc = 23509 | doi = 10.1073/pnas.94.21.11472 }}
  • {{cite journal | vauthors = Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D | title = The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities | journal = Cell | volume = 95 | issue = 2 | pages = 279–89 | date = Oct 1998 | pmid = 9790534 | doi = 10.1016/S0092-8674(00)81758-4 }}
  • {{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | date = Oct 1998 | pmid = 9804427 | doi = 10.1038/27699 }}
  • {{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = Aug 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}
  • {{cite journal | vauthors = Schmidt DR, Schreiber SL | title = Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4 | journal = Biochemistry | volume = 38 | issue = 44 | pages = 14711–7 | date = Nov 1999 | pmid = 10545197 | doi = 10.1021/bi991614n | citeseerx = 10.1.1.559.7745 }}
  • {{cite journal | vauthors = Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH | title = Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 9 | pages = 6817–24 | date = Mar 2001 | pmid = 11102443 | doi = 10.1074/jbc.M007372200 }}
  • {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
  • {{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}
  • {{cite journal | vauthors = Saito M, Ishikawa F | title = The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 38 | pages = 35434–9 | date = Sep 2002 | pmid = 12124384 | doi = 10.1074/jbc.M203455200 }}
  • {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = Feb 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
  • {{cite journal | vauthors = Kwan AH, Gell DA, Verger A, Crossley M, Matthews JM, Mackay JP | title = Engineering a protein scaffold from a PHD finger | journal = Structure | volume = 11 | issue = 7 | pages = 803–13 | date = Jul 2003 | pmid = 12842043 | doi = 10.1016/S0969-2126(03)00122-9 }}
  • {{cite journal | vauthors = Shimono Y, Murakami H, Kawai K, Wade PA, Shimokata K, Takahashi M | title = Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51638–45 | date = Dec 2003 | pmid = 14530259 | doi = 10.1074/jbc.M309198200 }}
  • {{cite journal | vauthors = Williams CJ, Naito T, Arco PG, Seavitt JR, Cashman SM, De Souza B, Qi X, Keables P, Von Andrian UH, Georgopoulos K | title = The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development | journal = Immunity | volume = 20 | issue = 6 | pages = 719–33 | date = Jun 2004 | pmid = 15189737 | doi = 10.1016/j.immuni.2004.05.005 }}
  • {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
{{refend}}{{PDB Gallery|geneid=1108}}{{gene-12-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/11 17:58:46