| 词条 | Chlorophenylbiguanide |
| 释义 |
| verifiedrevid = 414064127 | IUPAC_name = 2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine | image = Chlorophenylbiguanide.png | width = 240 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 2287 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 48144-44-1 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 910A4X901V | PubChem = 1354 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 27570 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 42752 | C=8 | H=12 | Cl=1 | N=5 | molecular_weight = 213.667 g/mol | smiles = c1ccc(Cl)cc1NC(=N)NC(=N)N | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C8H10ClN5/c9-5-3-1-2-4-6(5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = MKWFJPZMYHPQIA-UHFFFAOYSA-N }}meta-Chlorophenylbiguanide (1-(3-Chlorophenylbiguanide, m-CPBG) is an allosteric agonist and modulator of the 5-HT3 receptor[1][2][3] and an antagonist of the α2A-adrenergic receptor.[4] It has anxiogenic, emetic and hypothermic effects in animal studies.[5][6][7][8] See also
References1. ^{{cite journal |vauthors=Miles TF, Lester HA, Dougherty DA |title=Allosteric activation of the 5-HT3AB receptor by mCPBG |journal=Neuropharmacology |volume=91 |issue= |pages=103–8 |year=2015 |pmid=25541413 |doi=10.1016/j.neuropharm.2014.12.018 |pmc=4312754}} {{Adrenergics}}{{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Michaelson SD, Paulsen IM, Kozuska JL, Martin IL, Dunn SM |title=Importance of recognition loops B and D in the activation of human 5-HT₃ receptors by 5-HT and meta-chlorophenylbiguanide |journal=Neuropharmacology |volume=73 |issue= |pages=398–403 |year=2013 |pmid=23810831 |doi=10.1016/j.neuropharm.2013.06.017 |url=}} 3. ^{{cite journal |vauthors=Suryanarayanan A, Joshi PR, Bikádi Z, Mani M, Kulkarni TR, Gaines C, Schulte MK |title=The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide |journal=Biochemistry |volume=44 |issue=25 |pages=9140–9 |year=2005 |pmid=15966738 |doi=10.1021/bi050661e |url=}} 4. ^{{cite journal |vauthors=Schlicker E, Kathmann M, Exner HJ, Detzner M, Göthert M |year=1994 |title=the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of alpha 2-adrenoceptors in the mouse brain cortex |journal=Naunyn-Schmiedeberg's Archives of Pharmacology |volume=349 |issue= |pages=20–24 |pmid=7908122 |doi=10.1007/bf00178201}} 5. ^{{cite journal |vauthors=Andrews N, File SE |title=Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment? |journal=Psychopharmacology |volume=108 |issue=3 |pages=333–7 |year=1992 |pmid=1523283 |doi= 10.1007/BF02245120|url=}} 6. ^{{cite journal |vauthors=Dukat M, Young R, Darmani NN, Ahmed B, Glennon RA |title=The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay |journal=Psychopharmacology |volume=150 |issue=2 |pages=200–7 |date=June 2000 |pmid=10907673 |doi= 10.1007/s002130000410|url=}} 7. ^{{cite journal |vauthors=Castro L, Varjão B, Maldonado I, Campos I, Duque B, Fregoneze J, Reis de Oliveira I, De Castro-e-Silva E |title=Central 5-HT(3) receptors and water intake in rats |journal=Physiology & Behavior |volume=77 |issue=2–3 |pages=349–59 |date=November 2002 |pmid=12419412 |doi=10.1016/S0031-9384(02)00872-7 |url=}} 8. ^{{cite journal |vauthors=Naumenko VS, Kondaurova EM, Popova NK |title=Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor |journal=Neuroscience Letters |volume=465 |issue=1 |pages=50–4 |date=November 2009 |pmid=19735696 |doi=10.1016/j.neulet.2009.09.005 |url=}} 5 : 5-HT3 agonists|Alpha-2 blockers|Emetics|Guanidines|Chloroarenes |
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