| 词条 | CHRNA10 |
| 释义 |
Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.[1] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[2] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[3] References1. ^{{cite journal | vauthors = Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA | title = Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10) | journal = Genomics | volume = 73 | issue = 3 | pages = 272–83 |date=May 2001 | pmid = 11350119 | doi = 10.1006/geno.2000.6503 | url = }} 2. ^{{cite journal | vauthors = Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J | title = The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 51 | pages = 20594–9 |date=December 2007 | pmid = 18077337 | pmc = 2154476 | doi = 10.1073/pnas.0708545105 | url = }} 3. ^{{cite journal | vauthors = Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM | title = Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 47 | pages = 17880–4 |date=November 2006 | pmid = 17101979 | pmc = 1635975 | doi = 10.1073/pnas.0608715103 | url = }} External links
2 : Ion channels|Nicotinic acetylcholine receptors |
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