“CHRNA5”的意思、由来-开放百科全书

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.^[1]^[2] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.^[2]

Interactive pathway map

Further reading

{{cite journal | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue= |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 | series=Reviews of Physiology, Biochemistry and Pharmacology | isbn=978-3-540-01365-5 }}

{{cite journal | vauthors=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans |journal=Genomics |volume=13 |issue= 4 |pages= 962–7 |year= 1992 |pmid= 1505988 |doi=10.1016/0888-7543(92)90008-G }}

{{cite journal | vauthors=Chini B, Clementi F, Hukovic N, Sher E |title=Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1572–6 |year= 1992 |pmid= 1542648 |doi= 10.1073/pnas.89.5.1572| pmc=48494 }}

{{cite journal | author=Raimondi E |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits |journal=Genomics |volume=12 |issue= 4 |pages= 849–50 |year= 1992 |pmid= 1572664 |doi= 10.1016/0888-7543(92)90324-L |name-list-format=vanc| author2=Rubboli F | author3=Moralli D | display-authors=3 | last4=Chini | first4=Bice | last5=Fornasari | first5=Diego | last6=Tarroni | first6=Paola | last7=De Carli | first7=Luigi | last8=Clementi | first8=Francesco }}

{{cite journal | author=Elliott KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842 |name-list-format=vanc| author2=Ellis SB | author3=Berckhan KJ | display-authors=3 | last4=Urrutia | first4=Arturo | last5=Chavez-Noriega | first5=Laura E. | last6=Johnson | first6=Edwin C. | last7=Veliçelebi | first7=Gönül | last8=Harpold | first8=Michael M. }}

{{cite journal | vauthors=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–14 |year= 1997 |pmid= 9009220 |doi=10.1016/S0014-5793(96)01383-X }}

{{cite journal | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi= }}

{{cite journal | vauthors=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311–20 |year= 1998 |pmid= 9655874 |doi= }}

{{cite journal | author=Lentz TL |title=Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 480–4 |year= 2000 |pmid= 10679230 |doi= 10.1006/bbrc.2000.2155 }}

{{cite journal | vauthors=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789–96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313 | pmc=1573006 }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Soldà G |title=In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs |journal=Gene |volume=345 |issue= 2 |pages= 155–64 |year= 2005 |pmid= 15716100 |doi= 10.1016/j.gene.2004.12.005 |name-list-format=vanc| author2=Boi S | author3=Duga S | display-authors=3 | last4=Fornasari | first4=Diego | last5=Benfante | first5=Roberta | last6=Malcovati | first6=Massimo | last7=Tenchini | first7=Maria Luisa }}

Function

Interactive pathway map

See also

References

Further reading

External links