| 释义 |
- Function
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Acetylcholine receptor subunit delta is a protein that in humans is encoded by the CHRND gene.[1] Function The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.[1] Interactions CHRND has been shown to interact with Cholinergic receptor, nicotinic, alpha 1.[2][3] See also - Nicotinic acetylcholine receptor
References 1. ^1 {{cite web | title = Entrez Gene: CHRND cholinergic receptor, nicotinic, delta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1144| accessdate = }}
2. ^{{cite journal | vauthors = Kreienkamp HJ, Maeda RK, Sine SM, Taylor P | title = Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor | journal = Neuron | volume = 14 | issue = 3 | pages = 635–44 | date = March 1995 | pmid = 7695910 | doi = 10.1016/0896-6273(95)90320-8 }}
3. ^{{cite journal | vauthors = Wang ZZ, Hardy SF, Hall ZW | title = Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27575–84 | date = November 1996 | pmid = 8910344 | doi = 10.1074/jbc.271.44.27575 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Colledge M, Froehner SC | title = Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction | journal = Ann. N. Y. Acad. Sci. | volume = 841 | issue = | pages = 17–27 | year = 1998 | pmid = 9668219 | doi = 10.1111/j.1749-6632.1998.tb10907.x }}
- {{cite journal | vauthors = Beeson D, Jeremiah S, West LF, Povey S, Newsom-Davis J | title = Assignment of the human nicotinic acetylcholine receptor genes: the alpha and delta subunit genes to chromosome 2 and the beta subunit gene to chromosome 17 | journal = Ann. Hum. Genet. | volume = 54 | issue = Pt 3 | pages = 199–208 | year = 1990 | pmid = 2221824 | doi = 10.1111/j.1469-1809.1990.tb00378.x }}
- {{cite journal | vauthors = Luther MA, Schoepfer R, Whiting P, Casey B, Blatt Y, Montal MS, Montal M, Linstrom J | title = A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671 | journal = J. Neurosci. | volume = 9 | issue = 3 | pages = 1082–96 | year = 1989 | pmid = 2564429 | doi = }}
- {{cite journal | vauthors = Kreienkamp HJ, Maeda RK, Sine SM, Taylor P | title = Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor | journal = Neuron | volume = 14 | issue = 3 | pages = 635–44 | year = 1995 | pmid = 7695910 | doi = 10.1016/0896-6273(95)90320-8 }}
- {{cite journal | vauthors = Pasteris NG, Trask BJ, Sheldon S, Gorski JL | title = Discordant phenotype of two overlapping deletions involving the PAX3 gene in chromosome 2q35 | journal = Hum. Mol. Genet. | volume = 2 | issue = 7 | pages = 953–9 | year = 1993 | pmid = 8103404 | doi = 10.1093/hmg/2.7.953 }}
- {{cite journal | vauthors = Engel AG, Ohno K, Milone M, Wang HL, Nakano S, Bouzat C, Pruitt JN, Hutchinson DO, Brengman JM, Bren N, Sieb JP, Sine SM | title = New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome | journal = Hum. Mol. Genet. | volume = 5 | issue = 9 | pages = 1217–27 | year = 1996 | pmid = 8872460 | doi = 10.1093/hmg/5.9.1217 }}
- {{cite journal | vauthors = Wang ZZ, Hardy SF, Hall ZW | title = Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27575–84 | year = 1996 | pmid = 8910344 | doi = 10.1074/jbc.271.44.27575 }}
- {{cite journal | vauthors = Brownlow S, Webster R, Croxen R, Brydson M, Neville B, Lin JP, Vincent A, Newsom-Davis J, Beeson D | title = Acetylcholine receptor delta subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita | journal = J. Clin. Invest. | volume = 108 | issue = 1 | pages = 125–30 | year = 2001 | pmid = 11435464 | pmc = 209343 | doi = 10.1172/JCI12935 }}
- {{cite journal | vauthors = Gomez CM, Maselli RA, Vohra BP, Navedo M, Stiles JR, Charnet P, Schott K, Rojas L, Keesey J, Verity A, Wollmann RW, Lasalde-Dominicci J | title = Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms | journal = Ann. Neurol. | volume = 51 | issue = 1 | pages = 102–12 | year = 2002 | pmid = 11782989 | pmc = 4841278 | doi = 10.1002/ana.10077 }}
- {{cite journal | vauthors = Shen XM, Ohno K, Fukudome T, Tsujino A, Brengman JM, De Vivo DC, Packer RJ, Engel AG | title = Congenital myasthenic syndrome caused by low-expressor fast-channel AChR delta subunit mutation | journal = Neurology | volume = 59 | issue = 12 | pages = 1881–8 | year = 2002 | pmid = 12499478 | doi = 10.1212/01.wnl.0000042422.87384.2f }}
{{refend}} External links - {{MeshName|CHRND+protein,+human}}
- {{UCSC gene info|CHRND}}
{{NLM content}}{{Ligand-gated ion channels}}{{membrane-protein-stub}} 2 : Ion channels|Nicotinic acetylcholine receptors |