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词条 CHST11
释义

  1. Clinical relevance

  2. Model organisms

  3. References

  4. External links

  5. Further reading

{{Infobox_gene}}Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.[1][2]

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.[3]

Model organisms

Model organisms have been used in the study of CHST11 function. A conditional knockout mouse line called Chst11tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10] - in-depth bone and cartilage phenotyping[11]{{clear|left}}

References

1. ^{{cite journal | vauthors = Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M | title = Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family | journal = The Journal of Biological Chemistry | volume = 275 | issue = 26 | pages = 20188–96 | date = Jun 2000 | pmid = 10781601 | pmc = | doi = 10.1074/jbc.M002443200 }}
2. ^{{cite web | title = Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50515| accessdate = }}
3. ^{{cite journal | vauthors = Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O'Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Laughlin J | display-authors = 6 | title = Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study | journal = Lancet | volume = 380 | issue = 9844 | pages = 815–23 | date = Sep 2012 | pmid = 22763110 | doi = 10.1016/S0140-6736(12)60681-3 | pmc=3443899}}
4. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
5. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Chst11#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
6. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
7. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
8. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
9. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}
10. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Chst11&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}
11. ^1 {{cite web |url=http://www.boneandcartilage.com/ |title=OBCD Consortium}}

External links

  • {{UCSC gene info|CHST11}}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O | title = Molecular cloning and expression of chondroitin 4-sulfotransferase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 12 | pages = 8975–81 | date = Mar 2000 | pmid = 10722746 | doi = 10.1074/jbc.275.12.8975 }}
  • {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = Mar 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
  • {{cite journal | vauthors = Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O | title = Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase | journal = Journal of Biochemistry | volume = 128 | issue = 5 | pages = 763–70 | date = Nov 2000 | pmid = 11056388 | doi = 10.1093/oxfordjournals.jbchem.a022813 }}
  • {{cite journal | vauthors = Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K | title = Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36115–27 | date = Sep 2003 | pmid = 12847091 | doi = 10.1074/jbc.M306044200 }}
  • {{cite journal | vauthors = Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS | title = Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32) | journal = Oncogene | volume = 23 | issue = 41 | pages = 6991–6 | date = Sep 2004 | pmid = 15273723 | doi = 10.1038/sj.onc.1207934 }}
  • {{cite journal | vauthors = Yamada T, Ohtake S, Sato M, Habuchi O | title = Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues | journal = The Biochemical Journal | volume = 384 | issue = Pt 3 | pages = 567–75 | date = Dec 2004 | pmid = 15324304 | pmc = 1134142 | doi = 10.1042/BJ20040965 }}
  • {{cite journal | vauthors = Yusa A, Kitajima K, Habuchi O | title = N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1 | journal = The Biochemical Journal | volume = 388 | issue = Pt 1 | pages = 115–21 | date = May 2005 | pmid = 15628971 | pmc = 1186699 | doi = 10.1042/BJ20041573 }}
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