| 词条 | Cianopramine |
| 释义 |
| IUPAC_name = 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine-3-carbonitrile | image = Cianopramine V.1.svg | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 66834-24-0 | ATC_prefix = none | ATC_suffix = | PubChem = 48126 | ChEMBL = 2106504 | ChemSpiderID = 43782 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 02MNR4P2PM | C=20 | H=23 | N=3 | molecular_weight = 305.417 g/mol | smiles = N#Cc1ccc3c(c1)N(c2ccccc2CC3)CCCN(C)C }}Cianopramine (INN) (developmental code name Ro 11-2465), also known as 3-cyanoimipramine, is a tricyclic antidepressant related to imipramine that acts as a serotonin reuptake inhibitor[1] and weak serotonin receptor antagonist.[2][3] It was investigated for the treatment of depression but was never marketed.[3] See also
References1. ^Kenny M, Lenehan TJ, Lambe R, Darragh A, Brick I, Omer LM. Effects of a single oral dose of 3-cyano-imipramine on serotonin uptake and content of platelets in healthy volunteers. Psychopharmacology. 1983;79(4):304-7. {{PMID|6407042}} {{Antidepressants}}{{Anxiolytics}}{{Acetylcholine receptor modulators}}{{Adrenergic receptor modulators}}{{Histamine receptor modulators}}{{Monoamine reuptake inhibitors}}{{Serotonin receptor modulators}}{{Tricyclics}}{{nervous-system-drug-stub}}2. ^Pawłowski L, Kwiatek H, Górka Z. Is Ro 11-2465 (cyan-imipramine) an antagonist of postsynaptic serotonin receptors? Journal of Neural Transmission. 1981;52(1-2):61-72. {{PMID|7288439}} 3. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA270|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=270–}} 5 : Dibenzazepines|Nitriles|Tricyclic antidepressants|Selective serotonin reuptake inhibitors|Serotonin antagonists |
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