| 词条 | Cimoxatone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 443525672 | IUPAC_name = 3-[[4-[5-(methoxymethyl)-2-oxo-oxazolidin-3-yl]phenoxy]methyl]benzonitrile | image = Cimoxatone structure.svg | width = 250 | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 73815-11-9 | ATC_prefix = none | ATC_suffix = | PubChem = 52542 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2104092 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 47493 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = V6FT1QJ7VL | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D02581 | C=19 | H=18 | N=2 | O=4 | molecular_weight = 338.36 g/mol | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C19H18N2O4/c1-23-13-18-11-21(19(22)25-18)16-5-7-17(8-6-16)24-12-15-4-2-3-14(9-15)10-20/h2-9,18H,11-13H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = MVVJINIUPYKZHR-UHFFFAOYSA-N }} Cimoxatone (MD 780515) is a reversible inhibitor of MAO-A (RIMA).[1] It has a significant food interaction–related adverse effect in combination with tyramine.[2] It was never marketed. See also
References1. ^{{cite journal |vauthors=Nair NP, Ahmed SK, Kin NM, West TE |title=Reversible and selective inhibitors of monoamine oxidase A in the treatment of depressed elderly patients |journal=Acta Psychiatr Scand Suppl |volume=386 |issue= |pages=28–35 |year=1995 |pmid=7717092 |doi=10.1111/j.1600-0447.1995.tb05921.x}} {{Antidepressants}}{{Monoamine metabolism modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Nair NP, Ahmed SK, Kin NM |title=Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide |journal=J Psychiatry Neurosci |volume=18 |issue=5 |pages=214–25 |date=November 1993 |pmid=7905288 |pmc=1188542 }} 6 : Reversible inhibitors of MAO-A|Monoamine oxidase inhibitors|Nitriles|Phenol ethers|Oxazolidinones|Ethers |
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