| 释义 |
- Function
- Clinical significance
- Interactions
- References
- External links
- Further reading
{{Infobox_gene}}Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[1][2] Function The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[2] Clinical significance An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[3] Interactions CIZ1 has been shown to interact with P21.[1] References1. ^1 {{cite journal | vauthors = Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A | title = Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1 | journal = Biochem Biophys Res Commun | volume = 264 | issue = 2 | pages = 457–64 |date=Dec 1999 | pmid = 10529385 | pmc = | doi = 10.1006/bbrc.1999.1516 }}
2. ^1 {{cite web | title = Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25792| accessdate = }}
3. ^{{cite journal | vauthors = Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D | title = Variant Ciz1 is a circulating biomarker for early-stage lung cancer | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 109| issue = 45| pages = E3128–35|date=October 2012 | pmid = 23074256 | doi = 10.1073/pnas.1210107109 | url = | pmc = 3494940}}
External linksFurther reading{{refbegin | 35em}}- {{cite journal | vauthors=Lukasik A, Uniewicz KA, Kulis M, Kozlowski P |title=Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog. |journal=FEBS J. |volume=275 |issue= 2 |pages= 332–40 |year= 2008 |pmid= 18081865 |doi= 10.1111/j.1742-4658.2007.06203.x }}
- {{cite journal | vauthors=Rahman FA, Ainscough JF, Copeland N, Coverley D |title=Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1. |journal=Hum. Mutat. |volume=28 |issue= 10 |pages= 993–1004 |year= 2007 |pmid= 17508423 |doi= 10.1002/humu.20550 }}
- {{cite journal | vauthors=den Hollander P, Rayala SK, Coverley D, Kumar R |title=Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. |journal=Cancer Res. |volume=66 |issue= 22 |pages= 11021–9 |year= 2006 |pmid= 17108141 |doi= 10.1158/0008-5472.CAN-06-2336 }}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
- {{cite journal | vauthors=Coverley D, Marr J, Ainscough J |title=Ciz1 promotes mammalian DNA replication. |journal=J. Cell Sci. |volume=118 |issue= Pt 1 |pages= 101–12 |year= 2005 |pmid= 15585571 |doi= 10.1242/jcs.01599 }}
- {{cite journal | vauthors=Warder DE, Keherly MJ |title=Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC. |journal=J. Biomed. Sci. |volume=10 |issue= 4 |pages= 406–17 |year= 2004 |pmid= 12824700 |doi= 10.1159/000071160 }}
- {{cite journal | vauthors=Gilley J, Fried M |title=Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. |journal=Hum. Mol. Genet. |volume=8 |issue= 7 |pages= 1313–20 |year= 1999 |pmid= 10369878 |doi=10.1093/hmg/8.7.1313 }}
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